Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Tsubasa TanakaDepartment of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-8929-7474
Tamaki YanoGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.ORCID 0000-0002-5576-1128
Shingo UsukiLiaison Laboratory Research Promotion Center, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-9959-3322
Yoko SeoDepartment of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.
Kento MizutaDepartment of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.
Maho OkaguchiDepartment of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.
Maki YamaguchiDepartment of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.
Kazuko Hanyu-NakamuraDepartment of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.
Noriko Toyama-SorimachiDivision of Human Immunology, International Research and Development Center for Vaccines, The Institute of Medical Science, The University of Tokyo (IMSUT), Tokyo, Japan.
Katja BrücknerDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA.
Akira NakamuraDepartment of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. akiran@kumamoto-u.ac.jp.ORCID 0000-0001-6506-9146
Funding
MEXT | Japan Society for the Promotion of Science (JSPS) 17H03686MEXT | Japan Society for the Promotion of Science (JSPS) 21H02489MEXT | Japan Society for the Promotion of Science (JSPS) 21H04803MEXT | Japan Society for the Promotion of Science (JSPS) 22H02759MEXT | Japan Society for the Promotion of Science (JSPS) 23H00364Ministry of Education, Culture, Sports, Science and Technology (MEXT) JPMXP1323015486
6 · The paper itself
Abstract
RNA interference (RNAi) is a gene-silencing mechanism triggered by the cytosolic entry of double-stranded RNAs (dsRNAs). Many animal cells internalize extracellular dsRNAs via endocytosis for RNAi induction. However, it is not clear how the endocytosed dsRNAs are translocated into the cytosol across the endo/lysosomal membrane. Herein, we show that in Drosophila S2 cells, endocytosed dsRNAs induce lysosomal membrane permeabilization (LMP) that allows cytosolic dsRNA translocation. LMP mediated by dsRNAs requires the lysosomal Cl
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses. · full record | Socratic