ArticleNature2024
Recognition and control of neutrophil extracellular trap formation by MICL.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Turmeric-derived nanovesicles reprogram pathological NETosis to mitigate inflammatory bone loss.Journal of nanobiotechnology · 2026Article
- Roles of neutrophil extracellular traps in cancer immunotherapy resistance and therapeutic targeting.Biomarker research · 2026Review
- Ya Han Jie ameliorates adjuvant-induced arthritis by inhibiting the NF-κB/NETosis/inflammation axis.Chinese medicine · 2026Article
- Flipping sides in NETosis.Nature immunology · 2026Article
- Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection.Nature immunology · 2026Article
- Advances in immune cell-based therapeutic agents for the treatment of inflammation-related diseases.Acta pharmaceutica Sinica. B · 2026Review
- IL-17A Promotes NETs Formation via the PKCζ-ERK-ROS-PAD4 Pathway in a Mouse Model of Ischemic Stroke.CNS neuroscience & therapeutics · 2026Article
- Neutrophils as critical orchestrators of chronic inflammation.Cellular & molecular immunology · 2026Review
- Mitochondria as Inducers of Neutrophil Extracellular Traps.Inflammation · 2026Review
- NAC and DNase I synergistically reduce NETs to attenuate severe acute pancreatitis via suppressing the NETs/NF-κB/CXCL3 pathway.Apoptosis : an international journal on programmed cell death · 2026Article
- The Application Prospects and Future Outlook ofDrug design, development and therapy · 2026Review
- Neutrophil extracellular traps in antifungal immunity: mechanisms, dual roles, regulatory networks, and clinical perspectives.Frontiers in cellular and infection microbiology · 2026Review
- A feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin.Frontiers in immunology · 2026Article
- Characteristics of peripheral blood neutrophil subsets in patients with primary Sjogren's syndrome based on single-cell RNA sequencing.Frontiers in immunology · 2026Article
- Neutrophil Extracellular Traps in Systemic Lupus Erythematosus: Pathogenic Mechanisms, Crosstalk with Oxidative Stress, and Antioxidant Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2025Review
- Aloe-Emodin Targeting FOXC2 Disrupts NETs Formation and EMT-Driven Postoperative Peritoneal Adhesion Through TGF-β1-Smad2/3 Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A bismuth-based nanoplatform with synergistic fibrin/NET disruption and antioxidant/anti-inflammatory capabilities for enhanced thrombolysis and prevention of deep vein thrombosis recurrence.Journal of nanobiotechnology · 2025Article
- Article
- CLEC12A signaling represses protective immune responses and contributes to hippocampal pathology in neurotropic picornavirus infection.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Mariano MalamudMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Lauren WhiteheadInstitute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Alasdair McIntoshInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Fabio ColellaCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.
Anke J RoelofsCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.
Takato KusakabeJoan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, NY, USA.
Ivy M DambuzaMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID 0000-0001-6556-6476
Annie Phillips-BrookesMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Fabián SalazarMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Federico PerezProgram in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Romey ShoesmithMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID 0000-0001-6629-6172
Przemyslaw ZakrzewskiSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.ORCID 0000-0003-0035-5509
Emily A SeyMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Cecilia RodriguesMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Petruta L MorvayMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Pierre RedelinghuysInstitute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Tina BedekovicMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Maria J G FernandesFaculty of Medicine, Department of Microbiology, Infectious Diseases, and Immunology, Laval University, Quebec City, Quebec, Canada.
Ruqayyah AlmizraqMedical Affairs and Innovation, Canadian Blood Services, Toronto, Ontario, Canada.ORCID 0000-0001-8494-6538
Donald R BranchMedical Affairs and Innovation, Canadian Blood Services, Toronto, Ontario, Canada.
Borko AmulicSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Jamie HarveyMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Diane StewartInstitute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Raif YuecelCentre for Cytomics, University of Exeter, Exeter, UK.
Delyth M ReidInstitute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Alex McConnachieInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.ORCID 0000-0002-7262-7000
Matthew C PickeringDepartment of Immunology and Inflammation, Imperial College London, London, UK.ORCID 0000-0002-1153-0192
Marina BottoDepartment of Immunology and Inflammation, Imperial College London, London, UK.ORCID 0000-0002-1458-3791
Iliyan D IlievJoan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, NY, USA.ORCID 0000-0003-0884-9749
Iain B McInnesInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Cosimo De BariCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-5113-862X
Janet A WillmentMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID 0000-0002-7040-0857
Gordon D BrownMRC Centre for Medical Mycology, University of Exeter, Exeter, UK. gordon.brown@exeter.ac.uk.ORCID 0000-0002-0287-5383
Funding
Regulation and function of mucosal IgA immune responses to mycobiota in the gut.R01AI163007 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2021 to 2025
$2.9MMononuclear phagocyte networks in mycobiota regulation and antifungal immunity.R01DK121977 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2020 to 2024
$2.7MMedical Research Council MR/L020211/1Medical Research Council MR/N006364/1NIAID NIH HHS R01 AI163007NIDDK NIH HHS R01 DK121977Wellcome Trust
Abstract
Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular traps (NETs), which are web-like structures composed of DNA and neutrophil-derived proteins, are formed following pro-inflammatory signals; however, if this process is uncontrolled, NETs contribute to disease pathogenesis, exacerbating inflammation and host tissue damage
Indexed as
Arthritis, RheumatoidExtracellular TrapsNeutrophil ActivationNeutrophilsAnimalsAspergillus fumigatusAutoantibodiesCOVID-19Disease Models, AnimalDNAFeedback, PhysiologicalFemaleHumansInflammationLectins, C-TypeLupus Erythematosus, SystemicAutoantibodiesCLEC12A protein, humanCLEC12A protein, mouseDNALectins, C-TypePADI4 protein, humanpeptidylarginine deiminase 4, mouseProtein-Arginine Deiminase Type 4Reactive Oxygen SpeciesReceptors, Mitogen
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.