Evidence map›Paper›PMID 39143491›Full record

ArticleVeterinary research2024

TRIM5 inhibits the replication of Senecavirus A by promoting the RIG-I-mediated type I interferon antiviral response.

Huizi Li, Zhenxin Xie, Xiaoling Lei, Ming Chen, Tingting Zheng, Cunhao Lin, Zhangyong Ning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huizi Li *College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Zhenxin Xie *College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Xiaoling LeiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Ming ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Tingting ZhengCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Cunhao LinCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Zhangyong NingCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. ningzhyong@scau.edu.cn.ORCID http://orcid.org/0000-0002-0591-8588

Funding

Natural Science Foundation of Guangdong Province 2019A1515011735Project of Swine Innovation Team in Guangdong Modern Agricultural Research System 2020KJ126Start-up Research Project of Maoming Laboratory 2021TDQD002
6 · The paper itself

Abstract

Senecavirus A (SVA) is an emerging virus that poses a threat to swine herds worldwide. To date, the role of tripartite motif 5 (TRIM5) in the replication of viruses has not been evaluated. Here, TRIM5 was reported to inhibit SVA replication by promoting the type I interferon (IFN) antiviral response mediated by retinoic acid-inducible gene I (RIG-I). TRIM5 expression was significantly upregulated in SVA-infected cells, and TRIM5 overexpression inhibited viral replication and promoted IFN-α, IFN-β, interleukin-1beta (IL-1β), IL-6, and IL-18 expression. Conversely, interfering with the expression of TRIM5 had the opposite effect. Viral adsorption and entry assays showed that TRIM5 did not affect the adsorption of SVA but inhibited its entry. In addition, TRIM5 promoted the expression of RIG-I and RIG-I-mediated IFNs and proinflammatory cytokines, and this effect was also proven by inhibiting the expression of TRIM5. These findings expand the scope of knowledge on host factors inhibiting the replication of SVA and indicate that targeting TRIM5 may aid in the development of new agents against SVA.

Indexed as

Interferon Type IPicornaviridaeVirus ReplicationAnimalsSwineSwine DiseasesTripartite Motif ProteinsInterferon Type ITripartite Motif ProteinsIFNsinflammatory cytokinesRIG-ISenecavirus ATRIM5

Identifiers

PMID39143491
PMCPMC11323631

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.