Evidence map›Paper›PMID 39144548›Full record

ArticleACS pharmacology & translational science2024

Exploring an Intracellular Allosteric Site of CC-Chemokine Receptor 4 from 3D Models, Probe Simulations, and Mutagenesis.

Tianyi Ding, Abdul-Akim Guseinov, Graeme Milligan, Bianca Plouffe, Irina G Tikhonova

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tianyi DingSchool of Pharmacy, Queen's University Belfast, Belfast Bt9 7BL, Northern Ireland, U.K.
Abdul-Akim GuseinovSchool of Pharmacy, Queen's University Belfast, Belfast Bt9 7BL, Northern Ireland, U.K.
Graeme MilliganCentre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland G12 8QQ, U.K.
Bianca PlouffeWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast Bt9 7BL, Northern Ireland, U.K.ORCID https://orcid.org/0000-0002-8321-0796
Irina G TikhonovaSchool of Pharmacy, Queen's University Belfast, Belfast Bt9 7BL, Northern Ireland, U.K.ORCID https://orcid.org/0000-0002-6228-9431

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We applied our previously developed probe confined dynamic mapping protocol, which combines enhanced sampling molecular dynamics (MD) simulations and fragment-based approaches, to identify the binding site of GSK2239633A (

Identifiers

PMID39144548
PMCPMC11320731

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.