ReviewHeliyon2024
A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility.
Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Impact of Nano-Selenium supplementation on the JAK/STAT signaling pathway in major depressive disorder: a Triple-Blind, randomized controlled trial.BMC psychiatry · 2025Trial
- Effects of dietary nano-selenium and lysophospholipid supplementation on sperm quality and testicular histomorphometry in Moghani ram.Veterinary and animal science · 2026Article
- Comparative effects of Capsicum annuum selenium nanoparticles and sodium selenite on growth, antioxidant activity, bioaccumulation, and DNA damage in quails.Poultry science · 2026Article
- Methotrexate Alters Nrf2/HO-1 Protein Expression and Intrinsic Apoptosis-Associated Protein Responses in OVCAR-3 Ovarian Cancer Cells: Differential Modulation by Antioxidant Compounds.Journal of biochemical and molecular toxicology · 2026Article
- Metals/Metalloids Profile in Seminal Plasma/Serum of Patients with Asthenozoospermia/Oligozoospermia: Correlation with Semen Quality.Biological trace element research · 2026Article
- Form-specific selenium supplementation in poultry: linking bioefficacy to mechanisms and precision applications.Journal of animal science and biotechnology · 2026Review
- Effects of quercetin-loaded nanoselenium on spermatogenesis in a mouse model of cyclophosphamide-induced testicular damage.Clinical and experimental reproductive medicine · 2026Article
- Vascular Aging and Atherosclerosis: The Modulatory Impact of Selenium-A Comprehensive Review.Cells · 2026Review
- Essential Trace Elements in Commonly Consumed Varieties of Sri Lankan Cooked Rice and its Dietary Significance: A Focus on Recommended Daily Allowances.Biological trace element research · 2026Article
- Development and Characterization of a Guar Gum Bionanocomposite Loaded with Biogenic Selenium Nanoparticles and Its Cytotoxic Evaluation.Gels (Basel, Switzerland) · 2026Article
- Preventive Strategies and Biomarkers in Male Reproductive Health from Multidisciplinary Perspective: Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- The Effects of Graphene Oxide Nanoparticles on the Cryopreservation of Angora Buck Sperm.Molecules (Basel, Switzerland) · 2026Article
- A Comparative Review of Fertility and Semen Assessment Techniques in Farm Animals.Animals : an open access journal from MDPI · 2026Review
- Review
- Organic and inorganic selenium-enrichedFrontiers in nutrition · 2026Article
- Comparative Effects ofAnimals : an open access journal from MDPI · 2025Article
- Selenium as a Modulator of Reproductive Immunity: Molecular Insights and Translational Potential in Livestock.Reproduction in domestic animals = Zuchthygiene · 2025Review
- Protective effects of selenium nanoparticles against X-ray-induced testicular damage in rats: An integrated experimental and Monte Carlo simulation study.International journal of reproductive biomedicine · 2025Article
- Selenium: A Key Element in Inflammatory Bowel Disease.Antioxidants (Basel, Switzerland) · 2025Review
- Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management.Veterinary medicine and science · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium (Se), a component of selenoproteins and selenocompounds in the human body, is crucial for the development of male reproductive organs, DNA synthesis, thyroid hormone, metabolism, and defence against infections and oxidative damage. In the testis, it must exceed a desirable level since either a shortage or an overabundance causes aberrant growth. The antioxidant properties of selenium are essential for preserving human reproductive health. Selenoproteins, which have important structural and enzymatic properties, control the biological activities of Se primarily. These proteins specifically have a role in metabolism and a variety of cellular processes, such as the control of selenium transport, thyroid hormone metabolism, immunity, and redox balance. Selenium nanoparticles (SeNPs) are less hazardous than selenium-based inorganic and organic materials. Upon being functionalized with active targeting ligands, they are both biocompatible and capable of efficiently delivering combinations of payloads to particular cells. In this review, we discuss briefly the chemistry, structure and functions of selenium and milestones of selenium and selenoproteins. Next we discuss the various factors influences male infertility, biological functions of selenium and selenoproteins, and role of selenium and selenoproteins in spermatogenesis and male fertility. Furthermore, we discuss the molecular mechanism of selenium transport and protective effects of selenium on oxidative stress, apoptosis and inflammation. We also highlight critical contribution of selenium nanoparticles on male fertility and spermatogenesis. Finally ends with conclusion and future perspectives.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.