Evidence map›Paper›PMID 39145314›Full record

ArticleFrontiers in endocrinology2024

Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of oxytocin-elicited reductions of body weight and adiposity in male diet-induced obese mice.

Melise M Edwards, Ha K Nguyen, Andrew D Dodson, Adam J Herbertson, Tami Wolden-Hanson, Tomasz A Wietecha, Mackenzie K Honeycutt, Jared D Slattery, Kevin D O'Brien, James L Graham and 7 more

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Melise M EdwardsVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Ha K NguyenVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Andrew D DodsonVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Adam J HerbertsonVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Tami Wolden-HansonVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Tomasz A WietechaDivision of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Mackenzie K HoneycuttVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Jared D SlatteryVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Kevin D O'BrienDivision of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
James L GrahamDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Peter J HavelDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Thomas O MundingerDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Carl L SikkemaVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Elaine R PeskindVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
Vitaly RyuDepartment of Medicine and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Gerald J TaborskyVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.
James E BlevinsVA Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA, United States.

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Neuropathology and inflammation in a nonhuman primate model of insulin resistance/metabolic syndromeR01AG085572 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STEPHEN D GINSBERG, PETER J HAVEL · 2024 to 2026
$3.8M
Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resisR01HL091333 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J · 2008 to 2012
$2.0M
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemiaR01HL107256 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J, SCHWARZ, JEAN-MARC · 2011 to 2014
$1.5M
Role of Brown Adipose Tissue Thermogenesis in Oxytocin-Elicited Weight LossR01DK115976 · NIDDK · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI BLEVINS, JAMES ERNEST · 2018 to 2021
$1.4M
Role of Brown Adipose Tissue Thermogenesis in Oxytocin-Elicited Weight Loss in Rodents and Nonhuman PrimatesI01BX004102 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI James Ernest Blevins · 2018 to 2026
–
Role of Oxytocin Signaling in the Pathogenesis of Diet-Induced ObesityI01BX001213 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI BLEVINS, JAMES ERNEST · 2012 to 2015
–
BLRD VA I01 BX004102NHLBI NIH HHS R01 HL091333NHLBI NIH HHS R01 HL107256NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK115976
6 · The paper itself

Abstract

Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently demonstrated that hindbrain (fourth ventricular [4V]) administration of OT elicits weight loss and elevates interscapular brown adipose tissue temperature (T

Indexed as

Adipose Tissue, BrownAdiposityDiet, High-FatMice, Inbred C57BLObesityOxytocinSympathetic Nervous SystemAnimalsBody WeightEnergy MetabolismMaleMiceMice, ObeseNorepinephrineWeight LossNorepinephrineOxytocinbrown adipose tissue (BAT)food intakeobesityoxytocinwhite adipose tissue (WAT)

Identifiers

PMID39145314
PMCPMC11321955

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.