Evidence map›Paper›PMID 39145375›Full record

ArticleAngewandte Chemie (International ed. in English)2024

Enamine Synthesis via Regiocontrolled 6-endo-dig and 5-exo-dig Tethered Carboamination of Propargylic Alcohols.

Helena Solé-Àvila, Mikus Puriņš, Lucas Eichenberger, Jerome Waser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Alcohol-Directed Carboamination of Conjugated Enynes.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Helena Solé-ÀvilaLaboratory of Catalysis and Organic Synthesis and NCCR Catalysis, Institut des Sciences et Ingénierie Chimique, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
Mikus PuriņšLaboratory of Catalysis and Organic Synthesis and NCCR Catalysis, Institut des Sciences et Ingénierie Chimique, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-5818-176X
Lucas EichenbergerLaboratory of Catalysis and Organic Synthesis and NCCR Catalysis, Institut des Sciences et Ingénierie Chimique, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
Jerome WaserLaboratory of Catalysis and Organic Synthesis and NCCR Catalysis, Institut des Sciences et Ingénierie Chimique, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-4570-914X

Funding

École Polytechnique Fédérale de LausanneHORIZON EUROPE European Research Council ERC consolidator grant 771170
6 · The paper itself

Abstract

Enamines are versatile building blocks for the synthesis of biologically active compounds. Nevertheless, only a limited number of strategies have been reported for preparing trisubstituted enamines in a regio- and stereoselective manner. Herein, we report a regiocontrolled 6-endo and 5-exo tethered carboamination of propargylic alcohols for the synthesis of trisubstituted enamines. High regioselectivity was achieved through fine-tuning of the amine protecting group during the Pd-catalyzed carboamination. The introduced trifluoromethylated tether enables further stereoselective functionalizations, such as hydrogenation and fluorination.

Indexed as

amino alcoholcarboaminationenaminepalladium catalysisregioselective

Identifiers

PMID39145375
PMCPMC11609970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.