ReviewThe Journal of clinical investigation2024
Stress and substance use disorders: risk, relapse, and treatment outcomes.
Review in The Journal of clinical investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mental health outcomes associated with military sexual trauma in serving and ex-servicewomen: A systematic review.Psychological medicine · 2025Pooled it
- Efficacy of A Virtual Agent-Based Digital Intervention (Echo App V2.0) for Patients With Alcohol Use Disorder: Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Effects of suvorexant on diurnal cortisol and patient-reported stress during opioid withdrawal in a randomized trial.Psychoneuroendocrinology · 2025Trial
- Exercise as a Neurobiological Intervention: Utilizing NAc Circuitry to Combat Addiction.Addiction neuroscience · 2026Article
- Kappa opioid receptor-dependent depressive-like behaviors associated with morphine withdrawal contribute to stress-induced reinstatement of morphine seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Greater perceived stress and lower self-regulation associated with substance use behaviors in a national sample of United States emergency medical service clinicians.Drug and alcohol dependence · 2026Article
- Gender Differences in Adverse Childhood Experiences, Psychological Distress, and Substance Use Disorder Among Persons who Inject Drugs in Northeast Georgia, USA: A Moderated Mediation Analysis.Journal of child & adolescent trauma · 2026Article
- Perceived Social Support Moderates the Response to Stress and Alcohol Cues During Early Abstinence From Alcohol.Biological psychiatry global open science · 2026Article
- Craving mediates the association between affect and substance use in daily life among individuals with substance use disorders.Drug and alcohol dependence reports · 2026Article
- Forecasting stress transitions using ecological momentary assessment data and machine learning.Internet interventions · 2026Article
- Association between perceived stress and self-reported halitosis among university students: the mediating role of xerostomia, a cross-sectional study.BMC oral health · 2026Article
- Behavioral Impaired Control over Alcohol: Comparing Self-Medication and Behavioral Economic Models with the Interacting Effects of Acute Stress, Chronic Stress with Physical Neglect History, and Sex Assigned at Birth.Behavioral sciences (Basel, Switzerland) · 2026Article
- Voluntary wheel running prevented the short-term behavioural effects of vicarious intermittent social defeat in female mice.Psychopharmacology · 2026Article
- Addiction and chronic skin diseases: A Pan-European study on prevalence, associations and patient impact.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Depression in Opioid Use Disorder: A Tripartite Psychopathological Model for Dual Disorders.Journal of clinical medicine · 2026Article
- A neuroimmune framework for understanding adolescent stress and risk of alcohol misuse.Brain, behavior, & immunity - health · 2026Review
- Death anxiety and death-related depression in opioid use disorder: relationships with suicidal ideation, impulsivity, and psychological resilience.BMC psychiatry · 2026Article
- Infant caregiving, relational factors, mood, and pain in perinatal opioid use disorder: A prospective cohort with ecological momentary assessment.Addictive behaviors · 2026Article
- Associations Between 24-Hour Physical Behavior, Self-Perceived Stress, and Coping Self-Efficacy in Everyday Life: Ambulatory Assessment Study.JMIR mHealth and uHealth · 2026Article
- Association of stress-sensitive mid-insula activity with alcohol drinking and negative affect-like behavior during abstinence in mice.Neuropharmacology · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Stress has long been associated with substance misuse and substance use disorders (SUDs). The past two decades have seen a surge in research aimed at understanding the underlying mechanisms driving this association. This Review introduces a multilevel "adaptive stress response" framework, encompassing a stress baseline, acute reaction, and recovery with return-to-homeostasis phase that occurs at varying response times and across domains of analysis. It also discusses evidence showing the disruption of this adaptive stress response in the context of chronic and repeated stressors, trauma, adverse social and drug-related environments, as well as with acute and chronic drug misuse and with drug withdrawal and abstinence sequelae. Subjective, cognitive, peripheral, and neurobiological disruptions in the adaptive stress response phases and their link to inflexible, maladaptive coping; increased craving; relapse risk; and maintenance of drug intake are also presented. Finally, the prevention and treatment implications of targeting this "stress pathophysiology of addiction" are discussed, along with specific aspects that may be targeted in intervention development to rescue stress-related alterations in drug motivation and to improve SUD treatment outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.