Evidence map›Paper›PMID 39145786›Full record

ArticleInflammation2025

NDRG2 Deficiency Exacerbates UVB-Induced Skin Inflammation and Oxidative Stress Damage.

Lixia Zhang, Weijie Gu, Tian Liu, Haina Pei, Yulong Ma, Yi Zhao, Sha Huang, Minliang Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. NDRG2 deficiency exacerbates UVB-induced photodamage in human keratinocytes via impaired Nrf2-mediated antioxidant defense.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lixia Zhang *Department of Plastic and Reconstructive Surgery, Senior Department of Burn and Plastic Surgery, The Fourth Medical Center of Chinese, PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Weijie Gu *Department of Dermatology, Air Force Medical Center, Air Force Medical University, Beijing, 100142, China.
Tian Liu *Senior Department of Burn and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Haina PeiDepartment of Plastic and Reconstructive Surgery, Senior Department of Burn and Plastic Surgery, The Fourth Medical Center of Chinese, PLA General Hospital and PLA Medical College, Beijing, 100048, China.
Yulong MaDepartment of Anesthesiology, The First Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China.
Yi ZhaoDepartment of Dermatology, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China. zhaoyimd@tsinghua.edu.cn.
Sha HuangResearch Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, Chinese PLA General Hospital, PLA Medical College, Beijing, 100853, China. stellarahuang@sina.com.
Minliang ChenDepartment of Plastic and Reconstructive Surgery, Senior Department of Burn and Plastic Surgery, The Fourth Medical Center of Chinese, PLA General Hospital and PLA Medical College, Beijing, 100048, China. chenml@sohu.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

UVB radiation induces inflammatory and oxidative stress responses, contributing to skin damage, yet the underlying mechanisms are not fully understood. N-Myc downstream-regulated gene 2 (NDRG2), an emerging stress-associated gene, remains unexplored in UVB-induced skin injury. In this study, we detected skin NDRG2 expression after UVB irradiation for the first time and further used Ndrg2 knockout mice to clarify the role of NDRG2 in UVB-induced skin injury. Three-month-old male Ndrg2

Indexed as

Oxidative StressSkinUltraviolet RaysAdaptor Proteins, Signal TransducingAnimalsInflammationMaleMiceMice, KnockoutAdaptor Proteins, Signal TransducingNdr2 protein, mouseInflammationNDRG2Oxidative stressSkinUVB irradiation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.