Evidence map›Paper›PMID 39145869›Full record

SynthesisChirurgie (Heidelberg, Germany)2024

[Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review].

Jonas Dohmen, Nils Sommer, Katrin van Beekum, Jacob Nattermann, Christoph Engel, Jörg C Kalff, Robert Hüneburg, Tim O Vilz

Abstract readSystematic ReviewEnglish Abstract
PubMed Publisher
In one paragraph

Synthesis in Chirurgie (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonas DohmenKlinik und Poliklinik für Allgemein‑, Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland. Jonas.Dohmen@ukbonn.de.ORCID http://orcid.org/0000-0002-6907-3844
Nils SommerKlinik und Poliklinik für Allgemein‑, Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.
Katrin van BeekumMedizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, 53127, Bonn, Deutschland, Venusberg-Campus 1.
Jacob NattermannMedizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, 53127, Bonn, Deutschland, Venusberg-Campus 1.
Christoph EngelInstitut für Medizinische Informatik, Statistik und Epidemiologie (IMISE), Universität Leipzig, 04107, Leipzig, Deutschland.
Jörg C KalffKlinik und Poliklinik für Allgemein‑, Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.
Robert HüneburgMedizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, 53127, Bonn, Deutschland, Venusberg-Campus 1.
Tim O VilzKlinik und Poliklinik für Allgemein‑, Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented.

objectiveThis systematic review aims to investigate gender-specific differences in CRC development among LS patients. MATERIAL AND

methodsA systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria.

resultsMen have a higher risk of CRC and develop CRC earlier compared to women.

conclusionThese findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies.

Indexed as

Colorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisFemaleHumansMaleRisk FactorsSex FactorsAge at disease onsetCumulative riskGenderGeneticsSex

Identifiers

PMID39145869

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.