Evidence map›Paper›PMID 39146069›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2024

Longitudinal associations in dementia family caregivers of ambivalent feelings and disruptive behaviors with C-reactive protein, interleukin-6, and D-dimer.

Andrés Losada-Baltar, Brent T Mausbach, María Márquez-González, Rosa Romero-Moreno, Roland von Känel, Lucía Jiménez-Gonzalo, José A Fernandes-Pires, Samara Barrera-Caballero, Natalia Martín-María, Cristina Huertas-Domingo and 1 more

Abstract read
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Longitudinal associations in dementia family caregivers of ambivalent feelings and disruptive behaviors with C-reactive protein, interleukin-6, and D-dimer.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrés Losada-BaltarDepartamento de Psicologia, Universidad Rey Juan Carlos.ORCID 0000-0002-3134-7133
Brent T MausbachDepartment of Psychiatry, University of California, San Diego.
María Márquez-GonzálezDepartment of Biological and Health Psychology, Universidad Autonoma de Madrid.
Rosa Romero-MorenoDepartamento de Psicologia, Universidad Rey Juan Carlos.
Roland von KänelDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich (USZ).
Lucía Jiménez-GonzaloDepartamento de Psicologia, Universidad Rey Juan Carlos.
José A Fernandes-PiresDepartamento de Psicologia, Universidad Rey Juan Carlos.
Samara Barrera-CaballeroDepartamento de Psicologia, Universidad Rey Juan Carlos.
Natalia Martín-MaríaDepartment of Biological and Health Psychology, Universidad Autonoma de Madrid.
Cristina Huertas-DomingoDepartamento de Psicologia, Universidad Rey Juan Carlos.
Javier OlazaránDepartamento de Neurologia, Hospital General Universitario Gregorio Maranon.

Funding

Mobile, Web-based Behavioral Intervention for Improving Caregiver Well-beingR01AG061941 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAUSBACH, BRENT T · 2018 to 2022
$2.6M
Web-based Behavioral Activation for Alzheimer's CaregiversR21AG054119 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAUSBACH, BRENT T · 2016 to 2017
$426k
NIA NIH HHS R01 AG061941NIA NIH HHS R21 AG054119Spanish Ministry of EducationSpanish Ministry of Education and CultureSpanish Ministry of Science and InnovationUniversidad Rey Juan Carlos (URJC)
6 · The paper itself

Abstract

objectiveCaregivers' ambivalent feelings toward the care recipient have been found to be associated with depression and anxiety. There is no research linking caregivers' ambivalent feelings and cardiovascular risk. This study was aimed to analyze longitudinally the effect of ambivalence on caregivers' cardiovascular risk, defined by circulating levels of high-sensitivity C-reactive protein, interleukin-6 (IL-6), and D-dimer.

methodParticipants were 121 dementia family caregivers who were assessed three times during a 2-year period. Sociodemographic and health variables, behavioral and psychological symptoms of dementia (BPSD), ambivalent feelings, and C-reactive protein (CRP), IL-6, and D-dimer values were assessed. Mixed linear models were used to analyze the association between variables, including testing whether ambivalent feelings moderated the links between BPSD and biomarkers.

resultsIncreases over time in D-dimer were associated with increases in ambivalence, older age, female gender, and body mass index (BMI). Increases over time in CRP were associated with increases in BMI, older age, female gender, and the interaction of BPSD with caregivers' ambivalent feelings. The moderation analysis showed that increased BPSD was significantly associated with increased CRP when caregivers experienced high levels of ambivalence (

conclusionThe findings suggest that high ambivalent feelings are relevant for understanding cardiovascular vulnerability in dementia caregivers. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Indexed as

CaregiversC-Reactive ProteinDementiaFibrin Fibrinogen Degradation ProductsInterleukin-6AdultAgedAged, 80 and overBiomarkersEmotionsFemaleHumansLongitudinal StudiesMaleMiddle AgedBiomarkersC-Reactive ProteinFibrin Fibrinogen Degradation Productsfibrin fragment DIL6 protein, humanInterleukin-6

Identifiers

PMID39146069
PMCPMC11929127

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.