Evidence map›Paper›PMID 39146250›Full record

ReviewPhysiological reviews2025

The neurobiology of parenting and infant-evoked aggression.

Harris S Kaplan, Patricia M Horvath, Mohammed Mostafizur Rahman, Catherine Dulac

Abstract readReview
In one paragraph

Review in Physiological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026
    Review
  7. Article
  8. Article
  9. Neural plasticity supporting parental behaviors.Current opinion in neurobiology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Harris S KaplanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States.
Patricia M HorvathDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States.ORCID 0000-0001-9969-8637
Mohammed Mostafizur RahmanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States.ORCID 0000-0002-9355-4867
Catherine DulacDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States.ORCID 0000-0001-5024-5418

Funding

Microcircuits underlying murine parental behaviorR01HD082131 · NICHD · HARVARD UNIVERSITY · PI DULAC, CATHERINE · 2015 to 2024
$3.5M
Systems-Level and in Situ Transcriptomics Deconstruction of Neural Circuits Underlying Sensorimotor Transformation in an Innate BehaviorR01NS116593 · NINDS · HARVARD UNIVERSITY · PI DULAC, CATHERINE, MURTHY, VENKATESH N · 2023 to 2024
$2.7M
HHS | National Institutes of Health (NIH) R01HD082131HHS | National Institutes of Health (NIH) R01NS116593Howard Hughes Medical Institute (HHMI) NANICHD NIH HHS R01 HD082131NINDS NIH HHS R01 NS116593
6 · The paper itself

Abstract

Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization of individual priorities and physiology and is facilitated by combinatorial hormone action on specific cell types that are integrated throughout interconnected and brainwide neuronal circuits. In this review, we take a comprehensive approach to integrate historical and current literature on each of these topics across multiple species, with a focus on rodents. New and emerging molecular, circuit-based, and computational technologies have recently been used to address outstanding gaps in our current framework of knowledge on infant-directed behavior. This work is raising fundamental questions about the interplay between instinctive and learned components of parenting and the mutual regulation of affiliative versus agonistic infant-directed behaviors in health and disease. Whenever possible, we point to how these technologies have helped gain novel insights and opened new avenues of research into the neurobiology of parenting. We hope this review will serve as an introduction for those new to the field, a comprehensive resource for those already studying parenting, and a guidepost for designing future studies.

Indexed as

AggressionParentingAnimalsBrainHumansInfantInfant BehaviorNeurobiologybehaviorcell typescircuitshormonesparenting

Identifiers

PMID39146250
PMCPMC12208620

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.