Evidence map›Paper›PMID 39147228›Full record

ReviewEnvironmental pollution (Barking, Essex : 1987)2024

Dysregulated metabolic pathways associated with air pollution exposure and the risk of autism: Evidence from epidemiological studies.

Ni Kang, Suzan Sargsyan, Ino Chough, Lauren Petrick, Jiawen Liao, Wu Chen, Nathan Pavlovic, Frederick W Lurmann, Mayra P Martinez, Rob McConnell and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Environmental pollution (Barking, Essex : 1987), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ni KangDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Suzan SargsyanDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Ino ChoughDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Lauren PetrickDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Jiawen LiaoDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Wu ChenDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Nathan PavlovicSonoma Technology, Inc., Petaluma, CA, USA.
Frederick W LurmannSonoma Technology, Inc., Petaluma, CA, USA.
Mayra P MartinezDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Rob McConnellDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Anny H XiangDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Zhanghua ChenDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA. Electronic address: zhanghuc@usc.edu.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Environmental chemical mixtures and metabolomics in autism spectrum disorderR01ES031117 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PETRICK, LAUREN · 2020 to 2024
$3.3M
The Impact of Air Pollution Exposure on COVID-19 Severity and MortalityR01ES029963 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI MCCONNELL, ROB S, XIANG, ANNY H · 2019 to 2022
$3.3M
Metabolomic Signatures Linking Air Pollution, Obesity and DiabetesR00ES027870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHANGHUA · 2019 to 2021
$747k
Discovery of early life causes of autism spectrum disorder through retrospective metabolomics and proteome analysis of teethR21ES030882 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANDRA, SYAM S, PETRICK, LAUREN · 2019 to 2020
$466k
Effects of air pollution and gestational diabetes on autismR56ES028121 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI XIANG, ANNY H · 2017 to 2017
$250k
NCATS NIH HHS UL1 TR004419NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R00 ES027870NIEHS NIH HHS R01 ES029963NIEHS NIH HHS R01 ES031117NIEHS NIH HHS R21 ES030882NIEHS NIH HHS R56 ES028121
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a developmental disorder with symptoms that range from social and communication impairments to restricted interests and repetitive behavior and is the 4th most disabling condition for children aged 5-14. Risk factors of ASD are not fully understood. Environmental risk factors are believed to play a significant role in the ASD epidemic. Research focusing on air pollution exposure as an early-life risk factor of autism is growing, with numerous studies finding associations of traffic and industrial emissions with an increased risk of ASD. One of the possible mechanisms linking autism and air pollution exposure is metabolic dysfunction. However, there were no consensus about the key metabolic pathways and corresponding metabolite signatures in mothers and children that are altered by air pollution exposure and cause the ASD. Therefore, we performed a review of published papers examining the metabolomic signatures and metabolic pathways that are associated with either air pollution exposure or ASD risk in human studies. In conclusion, we found that dysregulated lipid, fatty acid, amino acid, neurotransmitter, and microbiome metabolisms are associated with both short-term and long-term air pollution exposure and the risk of ASD. These dysregulated metabolisms may provide insights into ASD etiology related to air pollution exposure, particularly during the perinatal period in which neurodevelopment is highly susceptible to damage from oxidative stress and inflammation.

Indexed as

Air PollutantsAir PollutionAutism Spectrum DisorderEnvironmental ExposureAutistic DisorderChildChild, PreschoolFemaleHumansMetabolic Networks and PathwaysRisk FactorsAir PollutantsAir pollution exposureAutism spectrum disorderMetabolic pathwayOxidative stress

Identifiers

PMID39147228
PMCPMC11902886

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.