ArticleSchizophrenia bulletin2025
A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology.
Article in Schizophrenia bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Gender differences in the association between anxiety and behavioral problems in 31,400 Chinese children: a cross-sectional regression and network analysis.BMC psychiatry · 2026Article
- Shared and distinct features between interpersonal and self-directed violent behaviors: a simulated intervention network study.BMC public health · 2026Article
- Linking spontaneous speech, cognition, and psychopathology across affective and psychotic disorders: A network approach.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Childhood maltreatment and adolescent non-suicidal self-injury: cross-sectional conditional process and network analyses of depressive symptoms and physical activity.Frontiers in psychiatry · 2026Article
- From childhood trauma to complex PTSD: a network analysis.European journal of psychotraumatology · 2025Article
- Network analysis of relationships among psychopathology, cognitive function, and psychosocial functioning in independent samples of Chinese with schizophrenia or bipolar disorder.Psychological medicine · 2025Article
- The relationship between self-reported adverse experiences and depressive symptoms among middle-aged and elderly individuals: A longitudinal study based on the CHARLS database.Brain, behavior, & immunity - health · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
background and hypothesisPsychiatric comorbidities suggest that symptoms overlap across different diagnoses; the transdiagnostic network approach is valuable for studying psychopathology. Childhood trauma is a common transdiagnostic risk factor for psychiatric disorders, but the complex relationship between childhood trauma and psychopathology has seldom been investigated using a large cross-sectional transdiagnostic sample. STUDY
designThis study recruited 869 patients with different diagnoses, including 418 schizophrenia, 215 bipolar disorder, and 236 major depressive disorder. Participants completed psychiatric interviews and self-report questionnaires. We constructed dimension- and item-level Least Absolute Shrinkage and Selection Operator-based (LASSO) networks to explore the relationship between childhood trauma, psychopathology, and duration of illness. Moreover, we constructed directed acyclic graphs (DAGs) to tentatively clarify the potential directions of associations among these variables. Network Comparison Tests (NCTs) were conducted for different diagnostic groups and gender-stratified groups. STUDY
resultsThe transdiagnostic LASSO networks showed that different types of childhood trauma exerted distinct impacts on various psychopathological dimensions. Emotional abuse was linked to depressive symptoms, physical abuse to excited symptoms, sexual abuse to positive and disorganized symptoms, emotional neglect to depressive symptoms and motivation and pleasure (MAP) deficits factor of negative symptoms, and physical neglect to MAP factor. The DAG findings generally concurred with the LASSO network. The NCT showed comparable networks.
conclusionsOur findings suggest that childhood trauma is significantly associated with the development of psychopathology across different diagnostic groups. The affective pathway model suggests that early identification and tailored interventions would be needed for people with a history of childhood trauma.
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