Evidence map›Paper›PMID 39148728›Full record

ArticleFrontiers in immunology2024

Immunological characterization and comparison of children with COVID-19 from their adult counterparts at single-cell resolution.

Ran Jia, Zifeng Li, Shiwen Hu, Hailing Chang, Mei Zeng, Pengcheng Liu, Lijuan Lu, Menghua Xu, Xiaowen Zhai, Maoxiang Qian and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The Immune System as a Biosensor of Health and Athletic Performance.Scandinavian journal of medicine & science in sports · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ran Jia *Department of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Zifeng Li *Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Shiwen Hu *Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Hailing ChangDepartment of Infectious Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Mei ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Pengcheng LiuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Lijuan LuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Menghua XuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiaowen Zhai *Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Maoxiang Qian *Institute of Pediatrics and Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Jin Xu *Department of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The immunological characteristics that could protect children with coronavirus disease 2019 (COVID-19) from severe or fatal illnesses have not been fully understood yet. Methods: Here, we performed single-cell RNA sequencing (scRNA-seq) analysis on peripheral blood samples of 15 children (8 with COVID-19) and compared them to 18 adults (13 with COVID-19). Results: The child-adult integrated single cell data indicated that children with the disease presented a restrained response to type I interferon in most of the major immune cell types, along with suppression of upstream interferon regulatory factor and toll-like receptor expression in monocytes, which was confirmed by Conclusion: Conclusively, this preliminary study revealed distinct cell frequency and activation status of major immune cell types, particularly more robust NK cell cytotoxicity in PBMC that might help protect children from severe COVID-19.

Indexed as

COVID-19Killer Cells, NaturalSARS-CoV-2Single-Cell AnalysisAdaptive ImmunityAdolescentAdultCellular SenescenceChildChild, PreschoolCytotoxicity, ImmunologicFemaleHumansInterferon Type IMaleMiddle AgedInterferon Type IchildrenCOVID-19innate immunityNK cellsingle-cell RNA sequencing

Identifiers

PMID39148728
PMCPMC11325098

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.