Evidence map›Paper›PMID 39148732›Full record

ArticleFrontiers in immunology2024

Formyl peptide receptor 2 regulates dendritic cell metabolism and Th17 cell differentiation during neuroinflammation.

Jong-Hyung Lim, Ales Neuwirth, Kyoung-Jin Chung, Sylvia Grossklaus, Oliver Soehnlein, George Hajishengallis, Triantafyllos Chavakis

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jong-Hyung Lim *Laboratory of Innate Immunity and Inflammation, Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Ales Neuwirth *Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Kyoung-Jin ChungInstitute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Sylvia GrossklausInstitute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Oliver SoehnleinInstitute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.
George Hajishengallis *Laboratory of Innate Immunity and Inflammation, Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Triantafyllos Chavakis *Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Funding

IL-22, Immune Plasticity, and Autotherapy in the PeriodontiumR01DE029436 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2020 to 2024
$1.9M
NIDCR NIH HHS R01 DE029436
6 · The paper itself

Abstract

Formyl peptide receptor 2 (FPR2) is a receptor for formylated peptides and specific pro-resolving mediators, and is involved in various inflammatory processes. Here, we aimed to elucidate the role of FPR2 in dendritic cell (DC) function and autoimmunity-related central nervous system (CNS) inflammation by using the experimental autoimmune encephalomyelitis (EAE) model. EAE induction was accompanied by increased

Indexed as

Cell DifferentiationDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalMice, KnockoutReceptors, Formyl PeptideTh17 CellsAnimalsCytokinesFemaleMiceMice, Inbred C57BLNeuroinflammatory DiseasesSpinal CordCytokinesformyl peptide receptor 2, mouseReceptors, Formyl Peptidedendritic cellsformyl peptide receptor 2metabolism experimental autoimmune encephalomyelitisnitric oxideTh17 cells

Identifiers

PMID39148732
PMCPMC11324504

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.