Evidence map›Paper›PMID 39148790›Full record

ArticleChemical science2024

Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy.

Christian Bonifer, Wiebke Hanke, Jonas Mühle, Frank Löhr, Johanna Becker-Baldus, Jessica Nagel, Gebhard F X Schertler, Christa E Müller, Gabriele M König, Daniel Hilger and 1 more

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christian BoniferInstitute of Biophysical Chemistry, Centre of Biomolecular Magnetic Resonance, Goethe University Frankfurt Max-von-Laue Str. 9 60438 Frankfurt Germany glaubitz@em.uni-frankfurt.de.ORCID https://orcid.org/0009-0002-7898-0849
Wiebke HankeInstitute for Pharmaceutical Biology, University of Bonn Nussallee 6 53115 Bonn Germany.
Jonas MühleDivision of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute Forschungsstr. 111, 5232 Villigen PSI Switzerland.
Frank LöhrInstitute of Biophysical Chemistry, Centre of Biomolecular Magnetic Resonance, Goethe University Frankfurt Max-von-Laue Str. 9 60438 Frankfurt Germany glaubitz@em.uni-frankfurt.de.ORCID https://orcid.org/0000-0001-6399-9497
Johanna Becker-BaldusInstitute of Biophysical Chemistry, Centre of Biomolecular Magnetic Resonance, Goethe University Frankfurt Max-von-Laue Str. 9 60438 Frankfurt Germany glaubitz@em.uni-frankfurt.de.ORCID https://orcid.org/0000-0003-1995-7323
Jessica NagelDepartment of Pharmaceutical & Medicinal Chemistry, Pharmaceutical Institute, University of Bonn An der Immenburg 4 53121 Bonn Germany.
Gebhard F X SchertlerDivision of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute Forschungsstr. 111, 5232 Villigen PSI Switzerland.ORCID https://orcid.org/0000-0002-5846-6810
Christa E MüllerDepartment of Pharmaceutical & Medicinal Chemistry, Pharmaceutical Institute, University of Bonn An der Immenburg 4 53121 Bonn Germany.ORCID https://orcid.org/0000-0002-0013-6624
Gabriele M KönigInstitute for Pharmaceutical Biology, University of Bonn Nussallee 6 53115 Bonn Germany.
Daniel HilgerDepartment of Pharmaceutical Chemistry, University of Marburg 35037 Marburg Germany daniel.hilger@pharmazie.uni-marburg.de.ORCID https://orcid.org/0000-0001-5179-1357
Clemens GlaubitzInstitute of Biophysical Chemistry, Centre of Biomolecular Magnetic Resonance, Goethe University Frankfurt Max-von-Laue Str. 9 60438 Frankfurt Germany glaubitz@em.uni-frankfurt.de.ORCID https://orcid.org/0000-0002-3554-6586

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cyclodepsipeptide FR900359 (FR) and its analogs are able to selectively inhibit the class of G

Identifiers

PMID39148790
PMCPMC11323312

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.