Evidence mapPaperPMID 39148821Full record

ArticlemedRxiv : the preprint server for health sciences2024

Association of Cardiologist Clinic Visits with Cardiovascular Primary Prevention Outcomes Among People with HIV from Underrepresented Racial and Ethnic Groups in the Southern United States.

Matthew S Durstenfeld, C Larry Hill, Robert M Clare, Karen Chiswell, Gretchen Sanders, Shamea Gray, Linda Cooper, Joseph Vicini, Keith Marsolo, Nwora Lance Okeke and 6 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Matthew S DurstenfeldDivision of Cardiology at Zuckerberg San Francisco General, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7612-3352
C Larry HillDuke Clinical Research Institute, Durham, North Carolina, USA.
Robert M ClareDuke Clinical Research Institute, Durham, North Carolina, USA.
Karen ChiswellDuke Clinical Research Institute, Durham, North Carolina, USA.ORCID 0000-0002-0279-9093
Gretchen SandersDuke Clinical Research Institute, Durham, North Carolina, USA.ORCID 0000-0001-5061-7947
Shamea GrayDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Linda CooperDivision of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.
Joseph ViciniDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Keith MarsoloDuke Clinical Research Institute, Durham, North Carolina, USA.
Nwora Lance OkekeDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Eric G MeissnerDivision of Infectious Diseases, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Kevin L ThomasDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-0040-5396
Caryn G MorseDivision of Infectious Diseases, Wake Forest Baptist Health, North Carolina, USA.
Gerald S BloomfieldDuke Clinical Research Institute, Durham, North Carolina, USA.ORCID 0000-0002-7176-1611
April C PettitDivision of Infectious Diseases & Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Chris T LongeneckerDivision of Cardiology & Department of Global Health, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9468-0179

Funding

The Impact of p53 Variants on Liver DiseaseP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2022 to 2025
$10.2M
Tennessee Center for AIDS Research (TN-CFAR)P30AI110527 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$1.7M
Low Cardiorespiratory Fitness and Chronotropic Incompetence inHIV: Risk Factors, Cardiovascular Implications, and Exercise Training as TreatmentK23HL172699 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$198k
A Clinic-Based Behavioral Intervention to Reduce Cardiovascular Disease Risk in Persons Living with HIVK23HL137611 · NHLBI · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2022 to 2022
$163k
NHLBI NIH HHS K12 HL143961NHLBI NIH HHS K23 HL137611NHLBI NIH HHS K23 HL172699NIAID NIH HHS P30 AI110527NIGMS NIH HHS P20 GM130457NIMHD NIH HHS R01 MD013493NIMH NIH HHS R01 MH113438
6 · The paper itself

Abstract

Background: People with HIV (PWH) are at elevated risk for atherosclerotic cardiovascular disease (ASCVD). Underrepresented racial and ethnic groups (UREGs) with HIV in the southern U.S. are disproportionately affected, yet whether cardiology specialist care for this at-risk group improves blood pressure and lipid control or prevents cardiovascular events is unknown. Methods: We evaluated a cohort of PWH from UREGs at elevated ASCVD risk without known cardiovascular disease who received HIV-related care from 2015-2018 at four academic medical centers in the Southern United States with follow up through 2020. Primary outcomes were blood pressure control (<140/90 mmHg) and lipid control (LDL-C ≤ 100 mg/dl) over 2 years and time to first major adverse cardiovascular (MACE) event. Statistical analyses were adjusted for cohort/site and patient factors including HIV measures and comorbidities. Results: Among 3972 included PWH (median age 47 years old, 32.6% female) without diagnosed cardiovascular disease, 276 (6.9%) had a cardiology clinic visit. Cardiology clinic visits were not significantly associated with subsequent blood pressure control (adjusted OR 0.78, 95% CI 0.49-1.24, p=0.29) or lipid control (adjusted OR 2.25, 95% CI 0.72-7.01, p=0.16). Over a median follow up of 5 years, patients who had a cardiology clinic visit had higher risk of MACE, overall mortality, and falsification endpoints (hospitalization or death from accident/trauma and pneumonia/sepsis) indicating a higher risk group overall, even after adjusting for measured risk factors. Conclusions: Among UREG PWH at elevated cardiovascular risk, a cardiology clinic visit was not associated with improved cardiovascular risk factors or reduced risk of cardiovascular events. Our study suggests that seeing a cardiologist is not alone sufficient to promote cardiovascular health or prevent cardiovascular events among PWH, but with low confidence given the higher risk among those who had a cardiology visit.

Indexed as

cardiovascular diseases specialtyHIVoutcomesprimary prevention

Identifiers

PMID39148821
PMCPMC11326318

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.