Evidence map›Paper›PMID 39149235›Full record

ArticlebioRxiv : the preprint server for biology2024

Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen.

Rachel Sharninghausen, Jiwon Hwang, Devon D Dennison, Ryan D Baldridge

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Rachel SharninghausenDepartment of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.
Jiwon HwangDepartment of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.
Devon D DennisonCellular and Molecular Biology Program, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.
Ryan D BaldridgeDepartment of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7158-7812

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Protein quality control at eukaryotic membranes.R35GM128592 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ryan Douglas Baldridge · 2018 to 2026
$3.3M
Quality control in the secretory pathwayF32GM136020 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLUMB, RACHEL STARR · 2020 to 2022
$149k
NIGMS NIH HHS F32 GM136020NIGMS NIH HHS R35 GM128592NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Degrons are minimal protein features that are sufficient to target proteins for degradation. In most cases, degrons allow recognition by components of the cytosolic ubiquitin proteasome system. Currently, all of the identified degrons only function within the cytosol. Using

Indexed as

degronsendoplasmic reticulum associated degradationERADHrd1 ubiquitin ligasemembrane proteinsprotein quality controlS. cerevisiaeTargeted protein degradationubiquitin

Identifiers

PMID39149235
PMCPMC11326120

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.