ArticlebioRxiv : the preprint server for biology2024
Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition.
Hannah N Wilkins, Stephen A Knerler, Ahmed Warshanna, Rodnie Colón Ortiz, Kate Haas, Benjamin C Orsburn, Dionna W Williams
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Hannah N WilkinsDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2682-4713 Stephen A KnerlerDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Ahmed WarshannaDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rodnie Colón OrtizDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-3977-1019 Kate HaasDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Benjamin C OrsburnDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dionna W WilliamsDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-5029-2628 Funding
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0MElucidating single cell changes in neurogenic brain regions during HIV and cannabinoid exposureU01DA058527 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Michael Jay Corley, Lishomwa C Ndhlovu · 2023 to 2026
$9.4MBiochemistry, Cellular and Molecular Biology Program: JHU BioGREAT (Biomedical Graduate REsiliency & Adaptability Training)T32GM144272 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Takanari Inoue · 2022 to 2026
$5.4MCannabidiol and Macrophage Chronic Inflammation in a Virally Suppressed Rhesus Macaque ModelR01DA052859 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WILLIAMS, DIONNA WHITNEY · 2020 to 2024
$3.6MCellular Signaling in Drug Induced ToxicityR01GM103853 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ORSBURN, BENJAMIN CARL · 2013 to 2022
$3.6MDrug Phosphorylation and AgingR01AG064908 · NIA · JOHNS HOPKINS UNIVERSITY · PI ORSBURN, BENJAMIN CARL · 2020 to 2023
$2.4MCOCAINE USE AND HIV ANTIRETROVIRAL THERAPY EFFICACY IN THE CNSR00DA044838 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WILLIAMS, DIONNA WHITNEY · 2019 to 2021
$817kNIAID NIH HHS P30 AI050409NIA NIH HHS R01 AG064908NIDA NIH HHS R00 DA044838NIDA NIH HHS R01 DA052859NIDA NIH HHS U01 DA058527NIGMS NIH HHS R01 GM103853NIGMS NIH HHS T32 GM144272
6 · The paper itselfAbstract
Therapeutically targeting the brain requires interactions with endothelial cells, pericytes, and astrocytes at the blood brain barrier (BBB). We evaluated regional and cell-type specific drug metabolism and transport mechanisms using rhesus macaques and
Indexed as
Antiretroviral therapyBlood brain barrierCentral nervous systemDrug dispositionDrug metabolismDrug transporterHIV
Identifiers
PMID39149336
PMCPMC11326144
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