Evidence map›Paper›PMID 39149393›Full record

ArticlebioRxiv : the preprint server for biology2024

An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins.

Alireza Ghanbarpour, Bertina Telusma, Barrett M Powell, Jia Jia Zhang, Isabella Bolstad, Carolyn Vargas, Sandro Keller, Tania Baker, Robert T Sauer, Joseph H Davis

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alireza GhanbarpourDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-7485-029X
Bertina TelusmaDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-6804-9527
Barrett M PowellDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0003-4228-2977
Jia Jia ZhangDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-3003-4485
Isabella BolstadDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0009-0002-5822-3680
Carolyn VargasBiophysics, Institute of Molecular Biosciences (IMB), NAWI Graz, University of Graz, Graz, Austria.
Sandro KellerBiophysics, Institute of Molecular Biosciences (IMB), NAWI Graz, University of Graz, Graz, Austria.ORCID 0000-0001-5469-8772
Tania BakerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-0737-3411
Robert T SauerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-1719-5399
Joseph H DavisDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-8858-8907

Funding

Tools to determine and analyze the structures of molecular machines in motionR01GM144542 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Joseph Davis · 2022 to 2026
$1.6M
Structure and function of ClpXPR35GM141517 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAUER, ROBERT T · 2021 to 2024
$1.5M
Quantitation and biochemical characterization of autophagy's role in agingR00AG050749 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DAVIS, JOSEPH HARRY · 2017 to 2019
$744k
NIA NIH HHS R00 AG050749NIGMS NIH HHS R01 GM144542NIGMS NIH HHS R35 GM141517
6 · The paper itself

Abstract

FtsH, a AAA protease, associates with HflK/C subunits to form a megadalton complex that spans the inner membrane and extends into the periplasm of

Identifiers

PMID39149393
PMCPMC11326279

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.