Evidence mapPaperPMID 39149405Full record

ArticlebioRxiv : the preprint server for biology2024

ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan.

Ekf Donahue, N L Hepowit, B Keuchel, A G Mulligan, D J Johnson, M Ellisman, R Arrojo E Drigo, J MacGurn, K Burkewitz

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ekf DonahueDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0002-7547-3959
N L HepowitDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0002-7614-2756
B KeuchelDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
A G MulliganDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0003-0793-9865
D J JohnsonDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
M EllismanNational Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-8893-8455
R Arrojo E DrigoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0001-7712-013X
J MacGurnDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
K BurkewitzDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · VANDERBILT UNIVERSITY MEDICAL CENTER · 1995 to 2025
$32.7M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · VANDERBILT UNIVERSITY · 2001 to 2005
$5.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · VANDERBILT UNIVERSITY · 1985 to 2005
$5.1M
Translational Analysis CoreP30DK058404 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2002 to 2025
$4.9M
SHOPP30EY008126 · VANDERBILT UNIVERSITY MEDICAL CENTER · 1989 to 2025
$4.0M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · 2024 to 2025
$3.2M
Vanderbilt Diabetes Research CenterP30DK020593 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$1.8M
Deciphering the ubiquitin code in stress signaling and membrane traffickingR35GM144112 · NIGMS · VANDERBILT UNIVERSITY · 2022 to 2025
$1.6M
TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGYT32HD007502 · VANDERBILT UNIVERSITY · 1997 to 2005
$1.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$455k
Targeting ER-mitochondrial calcium signaling to promote healthier agingR01AG073354 · VANDERBILT UNIVERSITY · 2025 to 2025
$318k
NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIA NIH HHS F31 AG076290NIA NIH HHS R00 AG052666NIA NIH HHS R01 AG073354NICHD NIH HHS T32 HD007502NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIGMS NIH HHS R35 GM144112NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIH HHS P40 OD010440
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) comprises an array of structurally distinct subdomains, each with characteristic functions. While altered ER-associated processes are linked to age-onset pathogenesis, whether shifts in ER morphology underlie these functional changes is unclear. We report that ER remodeling is a conserved feature of the aging process in models ranging from yeast to

Identifiers

PMID39149405
PMCPMC11326278

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.