Evidence map›Paper›PMID 39149411›Full record

ArticlemicroPublication biology2024

Replication forks associated with long nuclear actin filaments in mild stress conditions display increased dynamics.

Chiara Merigliano, Maria Dilia Palumbieri, Massimo Lopes, Irene Chiolo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Recent advances in nuclear actin research.Nucleus (Austin, Tex.) · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chiara MeriglianoMolecular and Computational Biology Department, University of Southern California, Los Angeles, United States.
Maria Dilia PalumbieriInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Massimo LopesInstitute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Irene ChioloMolecular and Computational Biology Department, University of Southern California, Los Angeles, United States.

Funding

Roles of nuclear architecture and phase separation in heterochromatin repair dynamicsR01GM117376 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIOLO, IRENE E · 2015 to 2023
$3.3M
NIGMS NIH HHS R01 GM117376
6 · The paper itself

Abstract

Nuclear actin filaments (F-actin) form during S-phase and in response to replication stress to promote fork remodeling and repair. In mild replication stress conditions, nuclear actin polymerization is required to limit PrimPol recruitment to the fork while promoting fork reversal. Both short and long filaments form during this response, but their function in the nuclear dynamics of replication sites was unclear. Here, we show that replication centers associated with long nuclear actin filaments become more mobile than the rest of the forks, suggesting relocalization of replication sites as a response to prolonged fork stalling and/or fork breakage, even in response to mild replication stress.

Identifiers

PMID39149411
PMCPMC11325199

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.