Evidence map›Paper›PMID 39149479›Full record

ArticleResearch square2024

Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes.

Sherry Jingjing Wu, Min Dai, Shang-Po Yang, Cai McCann, Yanjie Qiu, Giovanni J Marrero, Jeffrey A Stogsdill, Daniela J Di Bella, Qing Xu, Samouil L Farhi and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sherry Jingjing WuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Min DaiHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Shang-Po YangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Cai McCannSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0003-2010-9794
Yanjie QiuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Giovanni J MarreroBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jeffrey A StogsdillStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Daniela J Di BellaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0001-6141-3704
Qing XuCenter for Genomics & Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE.
Samouil L FarhiSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0003-1359-4568
Evan Z MacoskoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0002-2794-5165
Fei CheBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0003-2308-3649
Gord FishellHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0002-9640-9278

Funding

Comprehensive single-cell atlas of the developing mouse brainU01MH130962 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta, Tomasz Nowakowski · 2022 to 2026
$33.3M
The Development and Integration of Early Born SST-Expressing Interneurons in the CortexR01NS081297 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON J FISHELL · 2012 to 2026
$6.6M
The molecular and cellular basis of cortical interneuron divergenceR37MH071679 · NIMH · HARVARD MEDICAL SCHOOL · PI GORDON J FISHELL · 2022 to 2026
$4.1M
Cortical interneuron subtypes adapt to signals from local pyramidal cellsF32MH125464 · NIMH · HARVARD MEDICAL SCHOOL · PI WU, JINGJING · 2021 to 2023
$224k
NIMH NIH HHS F32 MH125464NIMH NIH HHS R37 MH071679NIMH NIH HHS U01 MH130962NINDS NIH HHS R01 NS081297
6 · The paper itself

Abstract

The mammalian cerebral cortex comprises a complex neuronal network that maintains a delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own research, have shown that specific interneuron subtypes are closely associated with particular pyramidal neuron types, forming stereotyped local inhibitory microcircuits. However, the developmental processes that establish these precise networks are not well understood. Here we show that pyramidal neuron types are instrumental in driving the terminal differentiation and maintaining the survival of specific associated interneuron subtypes. In a wild-type cortex, the relative abundance of different interneuron subtypes aligns precisely with the pyramidal neuron types to which they synaptically target. In

Identifiers

PMID39149479
PMCPMC11326388

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.