Evidence map›Paper›PMID 39150417›Full record

ArticleBiomaterials science2024

Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair.

Kyle B Timmer, Megan L Killian, Brendan A C Harley

Abstract read
In one paragraph

Article in Biomaterials science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Shaping the mechanical properties of a gelatin hydrogel interface via amination.Journal of the mechanical behavior of biomedical materials · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kyle B TimmerDept. Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, 110 Roger Adams Laboratory, 600 S. Mathews Ave., Urbana, IL 61801, USA. bharley@illinois.edu.ORCID http://orcid.org/0000-0001-6620-4290
Megan L KillianDepartment of Orthopaedic Surgery, University of Michigan Ann Arbor, Ann Arbor, Michigan 48109, USA.ORCID http://orcid.org/0000-0001-6868-5550
Brendan A C HarleyDept. Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, 110 Roger Adams Laboratory, 600 S. Mathews Ave., Urbana, IL 61801, USA. bharley@illinois.edu.ORCID http://orcid.org/0000-0001-5458-154X

Funding

Mineralized collagen composite to accelerate craniofacial bone regenerationR01DE030491 · NIDCR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HARLEY, BRENDAN A. · 2021 to 2025
$2.2M
Stratified and mechanically-tough biomaterial implant to improve tendon-to-bone enthesis regenerationR01AR077858 · NIAMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HARLEY, BRENDAN A. · 2021 to 2025
$1.7M
NIAMS NIH HHS R01 AR077858NIDCR NIH HHS R01 DE030491
6 · The paper itself

Abstract

Rotator cuff injuries present a clinical challenge for repair due to current limitations in functional regeneration of the native tendon-to-bone enthesis. A biomaterial that can regionally instruct unique tissue-specific phenotypes offers potential to promote enthesis repair. We have recently demonstrated the mechanical benefits of a stratified triphasic biomaterial made up of tendon- and bone-mimetic collagen scaffold compartments connected

Indexed as

Cell DifferentiationFibrocartilageGelatinHydrogelsMesenchymal Stem CellsParacrine CommunicationAggrecansBasic Helix-Loop-Helix ProteinsChondrogenesisCore Binding Factor Alpha 1 SubunitHumansRotator CuffRotator Cuff InjuriesSOX9 Transcription FactorTissue ScaffoldsACAN protein, humanAggrecansBasic Helix-Loop-Helix ProteinsCore Binding Factor Alpha 1 SubunitGelatinHydrogelsRUNX2 protein, humanSCX protein, humanSOX9 protein, humanSOX9 Transcription Factor

Identifiers

PMID39150417
PMCPMC11404831

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.