ReviewNature reviews. Endocrinology2024
Thyroid nodules: diagnosis and management.
Review in Nature reviews. Endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Bibliometric and Latent Dirichlet Allocation (LDA) analysis of artificial intelligence for thyroid nodules.Frontiers in endocrinology · 2026Pooled it
- Artificial intelligence in preoperative diagnosis of thyroid nodules: a bibliometric analysis.Frontiers in oncology · 2026Pooled it
- Mapping the giants: a bibliometric analysis of the top 100 most-cited thyroid nodules studies.Frontiers in medicine · 2025Pooled it
- Prevalence and risk of thyroid disease among adult primary aldosteronism patients: a systematic review, meta-analysis, and trial sequential analysis.Frontiers in endocrinology · 2025Pooled it
- Trial
- Article
- Article
- Evolution of thyroid fine-needle aspiration biopsy performance over 15 years: implications for risk stratification in clinical practice.Archives of endocrinology and metabolism · 2026Article
- The Performance of ChatGPT-4o and DeepSeek-R1 in Interpreting Thyroid Nodule Ultrasound Text Reports: Multicenter Study.Journal of medical Internet research · 2026Article
- Diagnostic Accuracy of Combined Fine-Needle Aspiration Biopsy and Ultrasonography for Malignancy in Bethesda III-IV Thyroid Nodules.Journal of clinical medicine · 2026Article
- Interpretable SVM-Based Integrated Ultrasound Model for Preoperative Thyroid Nodule Subtype Classification: Improved Identification of Follicular Variant Papillary Thyroid Carcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- 3D radiomics profiling of thyroid tumors using micro-CT.Scientific reports · 2026Article
- Machine learning approaches for predicting differentiated thyroid cancer recurrence using thyroglobulin levels and whole-body scans: a retrospective cohort study.Scientific reports · 2026Article
- Development of a predictive model using key ultrasound characteristics to distinguish follicular thyroid neoplasms from nodular goiter.Pakistan journal of medical sciences · 2026Article
- Predicting malignancy in solid thyroid nodules with no or punctate-linear enhancement on contrast-enhanced ultrasound: a retrospective analysis.Quantitative imaging in medicine and surgery · 2026Article
- Thyroid nodule and autoimmune thyroid disease frequency in adults with inborn errors of immunity: a case-control study.BMC immunology · 2026Article
- PKM2-Mediated Glycolytic Reprogramming in Thyroid Cancer: Mechanistic Insights and Therapeutic Potential.Molecules (Basel, Switzerland) · 2026Review
- Evaluation of large language models for TI-RADS category extraction from free-text thyroid US reports: a comparative study with human readers.Endocrine · 2026Article
- Clinical outcomes of lobectomy versus isthmusectomy for clinically node-negative solitary isthmic papillary thyroid microcarcinoma: a retrospective cohort study.Gland surgery · 2026Article
- Comprehensive evaluation of TIR 3B thyroid nodules: Clinical, Ultrasonographical and Cytological features for prediction of malignancy.Endocrine · 2026Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid nodules, with a prevalence of almost 25% in the general population, are a common occurrence. Their prevalence varies considerably depending on demographics such as age and sex as well as the presence of risk factors. This article provides a comprehensive overview of the prevalence, risk stratification and current management strategies for thyroid nodules, with a particular focus on changes in diagnostic and therapeutic protocols that have occurred over the past 10 years. Several sonography-based stratification systems (such as Thyroid Imaging Reporting and Data Systems (TIRADS)) might help to predict the malignancy risk of nodules, potentially eliminating the need for biopsy in many instances. However, large or suspicious nodules necessitate cytological evaluation following fine-needle aspiration biopsy for accurate classification. In the case of cytology yielding indeterminate results, additional tools, such as molecular testing, can assist in guiding the management plan. Surgery is no longer the only treatment for symptomatic or malignant nodules: active surveillance or local ablative treatments might be beneficial for appropriately selected patients. To enhance clinician-patient interactions and discussions about diagnostic options, shared decision-making tools have been developed. A personalized, risk-based protocol promotes high-quality care while minimizing costs and unnecessary testing.
Indexed as
Identifiers
39152228What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.