Evidence map›Paper›PMID 39152330›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Neuroretinal and microvascular retinal features in dementia with Lewy body assessed by optical coherence tomography angiography.

Giuseppe Maria Albanese, Magda Gharbiya, Giacomo Visioli, Massimiliano Panigutti, Andrea Margarella, Enrico Romano, Elvia Mastrogiuseppe, Micaela Sepe-Monti, Giuseppe Bruno, Fabrizia D'Antonio

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Intrinsic capacity in Lewy body dementia: a review.The Journal of frailty & aging · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giuseppe Maria AlbaneseDepartment of Sense Organs, Sapienza University of Rome, 155, Viale del Policlinico, Rome, 00161, Italy.
Magda GharbiyaDepartment of Sense Organs, Sapienza University of Rome, 155, Viale del Policlinico, Rome, 00161, Italy.
Giacomo VisioliDepartment of Sense Organs, Sapienza University of Rome, 155, Viale del Policlinico, Rome, 00161, Italy. giacomo.visioli@uniroma1.it.ORCID http://orcid.org/0000-0002-6152-433X
Massimiliano PaniguttiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, 00185, Italy.
Andrea MargarellaDepartment of Clinical Medicine, Public health, Life and Environmental Sciences, University of L'Aquila, L'Aquila, 67010, Italy.
Enrico RomanoDepartment of Sense Organs, Sapienza University of Rome, 155, Viale del Policlinico, Rome, 00161, Italy.
Elvia MastrogiuseppeDepartment of Sense Organs, Sapienza University of Rome, 155, Viale del Policlinico, Rome, 00161, Italy.
Micaela Sepe-MontiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, 00185, Italy.
Giuseppe BrunoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, 00185, Italy.
Fabrizia D'AntonioDepartment of Human Neurosciences, Sapienza University of Rome, Rome, 00185, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore retinal changes in patients with Dementia with Lewy Bodies (DLB) using Spectral Domain-Optical Coherence Tomography (SD-OCT) and Optical Coherence Tomography Angiography (OCTA), aiming to identify potential biomarkers for diagnosis and monitoring.

methodsA cross-sectional study analyzed 15 DLB patients and 18 matched controls. Participants underwent physical, neurological, neuropsychological, and ophthalmological evaluations, including SD-OCT and OCTA. Logistic regression, adjusted for age, sex, and inter-eye correlation, was employed to identify retinal alterations in patients affected by DLB.

resultsOCTA revealed that DLB is associated with reduced superficial and deep vessel densities (SVD and DVD) in the macula (p < 0.01), as well as decreased peripapillary vessel density (ppVD, p < 0.01). SD-OCT parameters showed correlations with DLB, including reduced central macular thickness (CMT, p < 0.001) and thinning of the ganglion cell layer-inner plexiform layer (GCL-IPL, p < 0.01). Logistic regression (R²=0.26) identified reduced ppVD as a significant predictor of DLB (p = 0.030).

conclusionsImpairments in retinal capillaries, especially lower ppVD, might mirror cerebral hypoperfusion in DLB, potentially due to reduced Vascular Endothelial Growth Factor (VEGF) levels and increased α-synuclein. Further investigations are warranted to confirm the causal relationship between these observations, disease severity, and progression, as well as their potential role as biomarkers for DLB.

Indexed as

Lewy Body DiseaseRetinal VesselsTomography, Optical CoherenceAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetinaDementia with Lewy Bodies (DLB)Neurodegenerative diseasesOptical Coherence Tomography Angiography (OCTA)Peripapillary vessel density (ppVD)Retinal BiomarkersRetinal changesRetinal Nerve Fiber Layer (RNFL)Vascular Endothelial Growth Factor (VEGF)

Identifiers

PMID39152330
PMCPMC11698750

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.