ArticleArthritis care & research2024
Family History of Arthritis, Osteoporosis, and Carpal Tunnel Syndrome and Risk of These Conditions Among US Adults.
Article in Arthritis care & research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Carpometacarpal Osteoarthritis Is Associated With an Increased Risk of Carpal Tunnel Syndrome.Journal of hand surgery global online · 2026Article
- A comparison of family health history of breast cancer, colorectal cancer, and diabetes in self-reported survey and electronic health records data, All of Us Research Program.Genetics in medicine open · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe aim was to estimate odds ratios (ORs) of associations between family history of arthritis, osteoporosis, and carpal tunnel syndrome and prevalence in a real-world population, uncovering family histories of related conditions that may increase risk because of shared heritability, condition pathophysiology, or social/environmental factors.
methodsUsing data from 156,307 participants in the All of Us (AoU) Research Program, we examined associations between self-reported first-degree family history of five common types of arthritis (fibromyalgia, gout, osteoarthritis [OA], rheumatoid arthritis, and systemic lupus erythematosus [SLE]), osteoporosis, and carpal tunnel syndrome and prevalence. We evaluate associations across seven conditions and performed stratified analyses by race and ethnicity, sex, socioeconomic differences, body mass index, and type of affected relative.
resultsMore than 38% of AoU participants reported a family history of any arthritis, osteoporosis, or carpal tunnel syndrome. Adults with a family history of any arthritis, osteoporosis, and carpal tunnel syndrome exhibited 3.68 to 7.59 (4.90, on average) odds of having the same condition and 0.70 to 2.10 (1.24, on average) odds of having a different condition. The strongest associations observed were between family history of OA and prevalence of OA (OR 7.59; 95% confidence interval [95% CI] 7.32-7.88) and family history of SLE and prevalence of SLE (OR 6.34; 95% CI 5.17-7.74). We additionally uncover race and ethnicity and sex disparities in family history associations.
conclusionFamily history of several related conditions was associated with increased risk for arthritis, osteoporosis, and carpal tunnel syndrome, underscoring the importance of family history of related conditions for primary prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.