Evidence mapPaperPMID 39155877Full record

ArticleInternational journal of oncology2024

Aurantio‑obtusin regulates lipogenesis and ferroptosis of liver cancer cells through inhibiting SCD1 and sensitizing RSL3.

Wen Liu, Jun Deng, Xiao-Jun Tao, Ya Peng, Xiang-Ding Chen, Xiao-Chao Qu, Hong-Wen Deng, Li-Jun Tan

Abstract read
In one paragraph

Article in International journal of oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wen LiuLaboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
Jun DengDepartment of Pharmacy, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410000, P.R. China.
Xiao-Jun TaoKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan 410013, P.R. China.
Ya PengDepartment of Pharmacy, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410000, P.R. China.
Xiang-Ding ChenLaboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
Xiao-Chao QuLaboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
Hong-Wen DengTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Li-Jun TanLaboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.

Funding

Tulane COBRE for Clinical and Translational Research in Cardiometabolic DiseasesP20GM109036 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$2.2M
Trans-omics Integration of Multi-omics Studies for OsteoporosisU19AG055373 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$2.1M
Intensive Lifestyle Intervention, Metabolomics, and Risk of Frailty Fracture in Overweight or Obese Patients with Type 2 DiabetesR01AG068232 · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2025 to 2025
$589k
NIA NIH HHS R01 AG068232NIA NIH HHS U19 AG055373NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

Ferroptosis, characterized by iron‑mediated non‑apoptotic cell death and alterations in lipid redox metabolism, has emerged as a critical process implicated in various cellular functions, including cancer. Aurantio‑obtusin (AO), a bioactive compound derived from Cassiae semen (the dried mature seeds of

Indexed as

FerroptosisLipogenesisLiver NeoplasmsStearoyl-CoA DesaturaseXenograft Model Antitumor AssaysAnimalsCarbolinesCell Line, TumorCell ProliferationDrug SynergismGene Expression Regulation, NeoplasticHep G2 CellsHumansMaleMiceSignal TransductionCarbolinesRSL3 compoundSCD1 protein, humanStearoyl-CoA DesaturaseTOR Serine-Threonine KinasesAOferroptosisGPX4liver cancerSCD1

Identifiers

PMID39155877
PMCPMC11374152

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.