Evidence map›Paper›PMID 39156619›Full record

ArticleNeuro-oncology advances

Directionally non-rotating electric field therapy delivered through implanted electrodes as a glioblastoma treatment platform: A proof-of-principle study.

Jun Ma, Shilpi Singh, Ming Li, Davis Seelig, Gregory F Molnar, Eric T Wong, Sanjay Dhawan, Stefan Kim, Logan Helland, David Chen and 4 more

Erratum issuedAbstract read
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In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jun MaDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
Shilpi SinghDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
Ming LiDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
Davis SeeligDepartment of Veterinary Clinic Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Gregory F MolnarSynerFuse Inc., Eden Prairie, Minnesota, USA.
Eric T WongDepartment of Neurology, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA.
Sanjay DhawanDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
Stefan KimDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
Logan HellandDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
David ChenDepartment of Neurosurgery, Taiwan Medical University, Taipei, Taiwan.
Nikos TapinosDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA.
Sean LawlerDepartment of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, Rhode Island, USA.
Gatikrushna SinghDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-9870-5556
Clark C ChenDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-9544-2570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While directionally rotating tumor-treating fields (TTF) therapy has garnered considerable clinical interest in recent years, there has been comparatively less focus on directionally non-rotating electric field therapy (dnEFT). Methods: We explored dnEFT generated through customized electrodes as a glioblastoma therapy in in vitro and in vivo preclinical models. The effects of dnEFT on tumor apoptosis and microglia/macrophages in the tumor microenvironment were tested using flow-cytometric and qPCR assays. Results: In vitro, dnEFT generated using a clinical-grade spinal cord stimulator showed antineoplastic activity against independent glioblastoma cell lines. In support of the results obtained using the clinical-grade electrode, dnEFT delivered through a customized, 2-electrode array induced glioblastoma apoptosis. To characterize this effect in vivo, a custom-designed 4-electrode array was fabricated such that tumor cells can be implanted into murine cerebrum through a center channel equidistant from the electrodes. After implantation with this array and luciferase-expressing murine GL261 glioblastoma cells, mice were randomized to dnEFT or placebo. Relative to placebo-treated mice, dnEFT reduced tumor growth (measured by bioluminescence) and prolonged survival (median survival gain of 6.5 days). Analysis of brain sections following dnEFT showed a notable increase in the accumulation of peritumoral macrophage/microglia with increased expression of M1 genes (IFNγ, TNFα, and IL-6) and decreased expression of M2 genes (CD206, Arg, and IL-10) relative to placebo-treated tumors. Conclusions: Our results suggest therapeutic potential in glioblastoma for dnEFT delivered through implanted electrodes, supporting the development of a proof-of-principle clinical trial using commercially available deep brain stimulator electrodes.

Indexed as

directionally non-rotating electric field therapy (dnEFT)electric stimulator electrodesglioblastomamacrophagesmicroglia

Identifiers

PMID39156619
PMCPMC11327618

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.