Evidence map›Paper›PMID 39158018›Full record

ArticleAging cell2024

Single-cell RNA sequencing reveals the CRTAC1

Yulong Tang, Dachun Zhuo, Yuexin Yu, Weilin Pu, Yanyun Ma, Yuting Zhang, Yan Huang, Qing Zhang, Kunhai Tang, Chen Meng and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. The Landscape of SPP1Immunology · 2025
    Review
  4. Article
  5. Semaglultide targets Spp1Journal of neuroinflammation · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yulong TangShanghai Key Laboratory of Vascular Lesions and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.ORCID 0000-0002-7794-2181
Dachun ZhuoShanghai Key Laboratory of Vascular Lesions and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.
Yuexin YuShanghai Key Laboratory of Vascular Lesions and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.
Weilin PuState Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Yanyun MaMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Yuting ZhangState Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Yan HuangState Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Qing ZhangState Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Kunhai TangState Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Chen MengShanghai Key Laboratory of Vascular Lesions and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.
Di YangShanghai Key Laboratory of Vascular Lesions and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.
Lu BaiShanghai Key Laboratory of Vascular Lesions and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.
Dongyi HeInstitute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Guanghua Integrative Medicine Hospital, Shanghai, China.
Li JinState Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Hejian ZouDivision of Rheumatology, Huashan Hospital, and Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
Huji XuDepartment of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Qi ZhuInstitute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Guanghua Integrative Medicine Hospital, Shanghai, China.
Jiucun WangState Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.
Yuanyuan ChenOrthopedic Department, Shanghai Sixth People's Hospital, Shanghai Jiaotong University Affiliated, Shanghai, China.
Jing LiuShanghai Key Laboratory of Vascular Lesions and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.ORCID 0000-0003-4346-0800

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-066Interdisciplinary Program of Shanghai Jiao Tong University YG2016MS15National Natural Science Foundation of China 82001726Science and Technology Commission of Shanghai Municipality 19JC1411702Scientific research project of Shanghai Health Commission 202040396Shanghai Municipal Science and Technology Major Project 2017SHZDZX01Shanghai Natural Science Foundation 21ZR1454400
6 · The paper itself

Abstract

Degenerative spinal stenosis is a chronic disease that affects the spinal ligaments and associated bones, resulting in back pain and disorders of the limbs among the elderly population. There are few preventive strategies for such ligament degeneration. We here aimed to establish a comprehensive transcriptomic atlas of ligament tissues to identify high-priority targets for pharmaceutical treatment of ligament degeneration. Here, single-cell RNA sequencing was performed on six degenerative ligaments and three traumatic ligaments to understand tissue heterogeneity. After stringent quality control, high-quality data were obtained from 32,014 cells. Distinct cell clusters comprising stromal and immune cells were identified in ligament tissues. Among them, we noted that collagen degradation associated with CTHRC1

Indexed as

MacrophagesSequence Analysis, RNAAnimalsHumansLigamentsMaleMiceOsteopontinSingle-Cell AnalysisOsteopontinSPP1 protein, humandegenerative lumbar spinal stenosisimmune regulationligament degenerationlow back painscRNA‐seq

Identifiers

PMID39158018
PMCPMC11634701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.