ArticleG3 (Bethesda, Md.)2024
Entomophthovirus: an insect-derived iflavirus that infects a behavior-manipulating fungal pathogen of dipterans.
Article in G3 (Bethesda, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- Mycoviruses in Entomopathogenic Fungi.Viruses · 2025Review
- Insights into diversity, host range, and evolution of iflaviruses in Lepidoptera through transcriptome mining.Virus evolution · 2025Article
- Virus replication in the honey bee parasite,Journal of virology · 2023Article
- Mycovirus-induced hypovirulence in notorious fungi Sclerotinia: a comprehensive review.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Review
- Divergent RNA viruses infecting sea lice, major ectoparasites of fish.PLoS pathogens · 2023Article
- Virome analysis of an ectomycorrhizal fungusFrontiers in cellular and infection microbiology · 2023Article
- Metatranscriptomic profiling reveals diverse tick-borne bacteria, protozoans and viruses in ticks and wildlife from Australia.Transboundary and emerging diseases · 2022Article
- Wolbachia reduces virus infection in a natural population of Drosophila.Communications biology · 2021Article
- The genus Entomophthora: bringing the insect destroyers into the twenty-first century.IMA fungus · 2021Review
- Diversity and infectivity of the RNA virome among different cryptic species of an agriculturally important insect vector: whitefly Bemisia tabaci.NPJ biofilms and microbiomes · 2021Article
- Insect Behavioral Change and the Potential Contributions of Neuroinflammation-A Call for Future Research.Genes · 2021Review
- Discovery and surveillance of viruses from salmon in British Columbia using viral immune-response biomarkers, metatranscriptomics, and high-throughput RT-PCR.Virus evolution · 2021Article
- Partitiviruses Infecting Drosophila melanogaster and Aedes aegypti Exhibit Efficient Biparental Vertical Transmission.Journal of virology · 2020Article
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- A new lineage of segmented RNA viruses infecting animals.Virus evolution · 2020Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report a virus infecting Entomophthora muscae, a behavior-manipulating fungal pathogen of dipterans. The virus, which we name Berkeley Entomophthovirus, is a positive-strand RNA virus in the iflaviridae family of capsid-forming viruses, which are mostly known to infect insects. The viral RNA is expressed at high levels in fungal cells in vitro and during in vivo infections of Drosophila melanogaster, and virus particles can be seen intracellularly in E. muscae. This virus, of which we find two closely related variants in our culture of E. muscae, is also closely related to three different viruses reported from metagenomic surveys, two of which were isolated from wild dipterans, and a third isolated from wild ticks. By analyzing sequencing data from these earlier reports, we find abundant reads aligning to E. muscae specifically in the samples from which viral reads were sequenced. These data establish a wide and perhaps obligate association with E. muscae in the wild, consistent with our laboratory data that E. muscae is the host for these closely related viruses. Because of this, we propose the name Entomophthovirus (EV) for this group of highly related virus variants. As other members of the iflaviridae have been reported to cause behavioral changes in insects, we speculate on the possibility that EV plays a role in the behavioral manipulation of flies infected with E. muscae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.