Evidence mapPaperPMID 39158346Full record

ArticleJournal of virology2024

Two novel compounds inhibit Flavivirus infection

Jiang-Fei Zhou, Meng-Ran Zhang, Qi Wang, Mei-Zhen Li, Ji-Shan Bai, Qi Dai, Yuan-Hang Zhang, Meng-Xue Yan, Xiao-Han Li, Jing Chen and 4 more

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Membrane-Targeting Antivirals.International journal of molecular sciences · 2025
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiang-Fei ZhouMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.ORCID 0009-0007-8288-2068
Meng-Ran ZhangMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Qi WangMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Mei-Zhen LiMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Ji-Shan BaiMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Qi DaiMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Yuan-Hang ZhangMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Meng-Xue YanState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Xiao-Han LiMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Jing ChenMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Ya-Yun LiuMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Chun-Chun LiuMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Jing YeState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-3258-6224
Bin ZhouMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0001-7279-9489

Funding

MOST | National Key Research and Development Program of China (NKPs) 2022YFD1800103
6 · The paper itself

Abstract

Flavivirus infection capitalizes on cellular lipid metabolism to remodel the cellular intima, creating a specialized lipid environment conducive to viral replication, assembly, and release. The Japanese encephalitis virus (JEV), a member of the IMPORTANCE: This study is the inaugural utilization of a lipid compound library in antiviral drug screening. Two lipid compounds, isobavachalcone (IBC) and corosolic acid (CA), emerged from the screening, exhibiting substantial inhibitory effects on the Japanese encephalitis virus (JEV) proliferation

Indexed as

AMP-Activated Protein KinasesAntiviral AgentsEncephalitis, JapaneseEncephalitis Virus, JapaneseLipid MetabolismVirus ReplicationAnimalsCell LineChalconesFlavivirusFlavivirus InfectionsHumansMiceTriterpenesViral Nonstructural ProteinsAMP-Activated Protein KinasesAntiviral AgentsChalconesTriterpenesViral Nonstructural Proteinsantiviralcorosolic acid (CA)Flavivirusisobavachalcone (IBC)Japanese encephalitis virus (JEV)lipid metabolism

Identifiers

PMID39158346
PMCPMC11406969

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.