Evidence map›Paper›PMID 39159075›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Automated Diagnosis and Phenotyping of Tuberculosis Using Serum Metabolic Fingerprints.

Yajing Liu, Ruimin Wang, Chao Zhang, Lin Huang, Jifan Chen, Yiqing Zeng, Hongjian Chen, Guowei Wang, Kun Qian, Pintong Huang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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  7. Automated Diagnosis and Phenotyping of Tuberculosis Using Serum Metabolic Fingerprints.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yajing LiuDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, P. R. China.
Ruimin WangState Key Laboratory for Oncogenes and Related Genes School of Biomedical Engineering Institute of Medical Robotics and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China.
Chao ZhangDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, P. R. China.
Lin HuangState Key Laboratory for Oncogenes and Related Genes School of Biomedical Engineering Institute of Medical Robotics and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China.
Jifan ChenDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, P. R. China.
Yiqing ZengDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, P. R. China.
Hongjian ChenPost-Doctoral Research Center, Zhejiang SUKEAN Pharmaceutical Co., Ltd, Hangzhou, 311225, P. R. China.
Guowei WangDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, P. R. China.
Kun QianState Key Laboratory for Oncogenes and Related Genes School of Biomedical Engineering Institute of Medical Robotics and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China.
Pintong HuangDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, P. R. China.ORCID 0000-0003-0747-5765

Funding

Innovative Research Team of High-level Local University in Shanghai SHSMU-ZDCX20210700Key Research and Development Program of Zhejiang Province 2019C03077National Natural Science Foundation of China 82001818National Natural Science Foundation of China 82030048National Natural Science Foundation of China 82102191National Natural Science Foundation of China 82230069Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning 2021-01-07-00-02-E00083Science and Technology Commission of Shanghai Municipality 2021SHZDZXScience and Technology Commission of Shanghai Municipality 20DZ2220400Shanghai Municipal Education Commission ZXWF082101Shanghai Municipal Health Commission 2019CXJQ03Sichuan Provincial Department of Science and Technology 2024YFHZ0176Zhejiang Science and Technology Project LQ21H180007
6 · The paper itself

Abstract

Tuberculosis (TB) stands as the second most fatal infectious disease after COVID-19, the effective treatment of which depends on accurate diagnosis and phenotyping. Metabolomics provides valuable insights into the identification of differential metabolites for disease diagnosis and phenotyping. However, TB diagnosis and phenotyping remain great challenges due to the lack of a satisfactory metabolic approach. Here, a metabolomics-based diagnostic method for rapid TB detection is reported. Serum metabolic fingerprints are examined via an automated nanoparticle-enhanced laser desorption/ionization mass spectrometry platform outstanding by its rapid detection speed (measured in seconds), minimal sample consumption (in nanoliters), and cost-effectiveness (approximately $3). A panel of 14 m z

Indexed as

BiomarkersMetabolomicsPhenotypeTuberculosisAdultCOVID-19FemaleHumansMachine LearningMaleMiddle AgedSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiomarkersdiagnosis and phenotypingdrug resistant tuberculosisnanoparticle enhanced laser desorption/ionization mass spectrometryserum metabolic fingerprintstuberculosis

Identifiers

PMID39159075
PMCPMC11497029

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.