Evidence map›Paper›PMID 39160436›Full record

ArticleAnalytical and bioanalytical chemistry2024

Carbon-13-isotopomics and metabolomics of fatty acids from triacylglycerols: overcoming the limitations of GC-C-IRMS for short- and medium-acyl chains.

Tania Mhanna, Mathilde Grand, Anne-Marie Schiphorst, Romain Le Balch, Toufic Rizk, Joseph Bejjani, Gérald S Remaud, Illa Tea

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tania MhannaCEISAM, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Nantes University-CNRS UMR 6230, 2 Rue de La Houssinière, BP 92208, 44322, Nantes Cedex 3, France.ORCID http://orcid.org/0009-0003-9471-6105
Mathilde GrandCEISAM, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Nantes University-CNRS UMR 6230, 2 Rue de La Houssinière, BP 92208, 44322, Nantes Cedex 3, France.
Anne-Marie SchiphorstCEISAM, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Nantes University-CNRS UMR 6230, 2 Rue de La Houssinière, BP 92208, 44322, Nantes Cedex 3, France.
Romain Le BalchCEISAM, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Nantes University-CNRS UMR 6230, 2 Rue de La Houssinière, BP 92208, 44322, Nantes Cedex 3, France.
Toufic RizkLMFI, Laboratory of Metrology and Isotopic Fractionation, Research Unit: Technologies Et Valorisation Agroalimentaire (TVA), Faculty of Science, Saint Joseph University of Beirut, Mar Mikhael, P.O. Box 17-5208, Beirut, 1104 2020, Lebanon.
Joseph BejjaniLMFI, Laboratory of Metrology and Isotopic Fractionation, Research Unit: Technologies Et Valorisation Agroalimentaire (TVA), Faculty of Science, Saint Joseph University of Beirut, Mar Mikhael, P.O. Box 17-5208, Beirut, 1104 2020, Lebanon.
Gérald S RemaudCEISAM, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Nantes University-CNRS UMR 6230, 2 Rue de La Houssinière, BP 92208, 44322, Nantes Cedex 3, France.
Illa TeaCEISAM, Interdisciplinary Chemistry: Synthesis, Analysis, Modeling, Nantes University-CNRS UMR 6230, 2 Rue de La Houssinière, BP 92208, 44322, Nantes Cedex 3, France. illa.tea@univ-nantes.fr.

Funding

French National Infrastructure for Metabolomics and Fluxomics MetaboHUB-ANR-11-INBS-0010
6 · The paper itself

Abstract

Carbon-13 isotopomics of triacylglycerol (TAG) fatty acids or free fatty acids in biological matrices holds considerable potential in food authentication, forensic investigations, metabolic studies, and medical research. However, challenges arise in the isotopic analysis of short- and medium-chain (C4 to C10) fatty acid methyl esters (SMCFAMEs) through gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS). The high volatility of these esters results in losses during their preparation, leading to isotopic fractionation. Moreover, the methoxy group added to acyl chains requires the correction of δ

Indexed as

Carbon IsotopesFatty AcidsGas Chromatography-Mass SpectrometryMetabolomicsTriglyceridesAnimalsReproducibility of ResultsCarbon-13Carbon IsotopesFatty AcidsTriglyceridesFree fatty acidsGas chromatography-combustion-isotope ratio mass spectrometryGreen analytical chemistryIsotopomics

Identifiers

PMID39160436

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.