ArticleParasites & vectors2024
Feline leishmaniosis in the Mediterranean Basin: a multicenter study.
Article in Parasites & vectors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Strategic surveillance plan for zoonotic leishmaniosis in Portugal.One health (Amsterdam, Netherlands) · 2026Article
- LeishVet update and current recommendations on feline leishmaniosis.Parasites & vectors · 2026Review
- Integrated One Health surveillance of human, canine and sand fly Leishmania infantum transmission in Sicily, southern Italy.Parasites & vectors · 2026Article
- Canine leishmaniosis on Favignana Island: a prospective observational study on infection dynamics, clinical outcomes and field safety in dogs receiving both vaccination (LETIFENDParasites & vectors · 2026Article
- Diagnostic potential of a multi-antigen ELISA for feline leishmaniosis.Parasites & vectors · 2026Article
- Seroprevalence ofMicroorganisms · 2026Article
- Cytokine gene expression in feline leishmaniasis: why cats might be less clinically affected than dogs.Parasites & vectors · 2026Article
- When Precision Matters: Bone Marrow Cytology Meets qPCR in a Pilot Study QuantifyingMicroorganisms · 2025Article
- Leishmania (Leishmania) infantum and Leishmania (Sauroleishmania) tarentolae in outdoor cats and report of infection in feline-derived peripheral blood mononuclear cells.Parasites & vectors · 2025Article
- A simplified system for the detection of antennal responses to host-borne volatile organic compounds in sand flies.Parasites & vectors · 2025Article
- Feline Leishmaniosis: A Retrospective Study of Seroprevalence in Cats in the Campania Region, Southern Italy.Animals : an open access journal from MDPI · 2025Article
- First report of a cat (Felis catus) infected by Leishmania (Viannia) guyanensis from Southeastern Brazil.Veterinary research communications · 2025Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCats are now recognized as competent hosts for Leishmania infantum and a blood source for sand fly vectors. Although canine leishmaniosis (CanL) is endemic in Mediterranean Basin countries, large-scale epidemiological studies are lacking for feline leishmaniosis (FeL). This study aimed to assess the prevalence of L. infantum infections, associated risk factors, clinical signs, and clinicopathological abnormalities in domestic cat populations from six Mediterranean Basin countries.
methodsFrom 2019 to 2022, blood and serum samples of cats (n = 2067) living in Italy (n = 300), Greece (n = 297), Portugal (n = 295), France (n = 231), Israel (n = 313), and Spain (n = 631) were collected along with animal data (i.e., age, sex, breed, housing conditions, and geographical origin), clinical signs, and laboratory blood test parameters. Cats were grouped according to their age as kittens (up to 1 year), young (older than 1 and younger than 7 years), mature (between 7 and 10 years), and senior (older than 10 years). Serum samples were tested for L. infantum by immunofluorescence antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA), and blood samples of seropositive cats were tested for L. infantum kinetoplast deoxyribonucleic acid (kDNA). Viral infection by feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) was molecularly addressed in all cats enrolled. Statistical analysis was performed to evaluate the association between the risk of L. infantum infection and independent variables, and among co-infection of L. infantum with FIV and/or FeLV, clinical signs, and clinicopathological abnormalities.
resultsOverall, 17.3% (358/2067) of cats scored positive for L. infantum by serological tests. Specifically, 24.7% were from Portugal, 23.2% from Greece, 16.6% from Israel, 15% from Spain, 13.3% from France, and 12.6% from Italy. Leishmania infantum DNA was detected in 15 seropositive animals. Housing condition and FIV infection proved to be risk factors for FeL. Leishmania seropositivity was significantly associated with weight loss, lymphadenomegaly, gingivostomatitis, and oral ulcers, as well as with reduced albumin and albumin/globulin ratio, increased total globulins and total proteins, leukocytosis, and thrombocytosis.
conclusionsThis study provides, for the first time, a large-scale epidemiological survey on FeL and its clinical presentation, revealing that L. infantum circulates among domestic cats, especially shelter/free-roaming and FIV-infected animals, living in CanL endemic countries of the Mediterranean Basin.
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