Evidence map›Paper›PMID 39160681›Full record

ArticleJournal of chemical theory and computation2024

Kinetic Diagram Analysis: A Python Library for Calculating Steady-State Observables of Biochemical Systems Analytically.

Nikolaus Carl Awtrey, Oliver Beckstein

Abstract read
In one paragraph

Article in Journal of chemical theory and computation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Nikolaus Carl AwtreyDepartment of Physics, Arizona State University, Tempe, Arizona 85287, United States.ORCID 0009-0000-0395-6284
Oliver BecksteinDepartment of Physics, Arizona State University, Tempe, Arizona 85287, United States.ORCID 0000-0003-1340-0831

Funding

Molecular mechanisms of secondary active transportersR01GM118772 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI BECKSTEIN, OLIVER · 2016 to 2020
$1.5M
NIGMS NIH HHS R01 GM118772
6 · The paper itself

Abstract

Kinetic diagrams are commonly used to represent biochemical systems in order to study phenomena such as free energy transduction and ion selectivity. While numerical methods are commonly used to analyze such kinetic networks, the diagram method by King, Altman and Hill makes it possible to construct exact algebraic expressions for steady-state observables in terms of the rate constants of the kinetic diagram. However, manually obtaining these expressions becomes infeasible for models of even modest complexity as the number of the required intermediate diagrams grows with the factorial of the number of states in the diagram. We developed

Indexed as

SoftwareKinetics

Identifiers

PMID39160681
PMCPMC11530140

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.