Evidence map›Paper›PMID 39161803›Full record

ArticlePatient preference and adherence2024

Treatment Preferences Among Patients with Renal Cell Carcinoma: Results from a Discrete Choice Experiment.

Moshe C Ornstein, Lisa C Rosenblatt, Xin Yin, Viviana Del Tejo, Sarah B Guttenplan, Flavia Ejzykowicz, Kathleen Beusterien, Oliver Will, deMauri S Mackie, Grace Skiles and 1 more

Abstract read
In one paragraph

Article in Patient preference and adherence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Moshe C OrnsteinTaussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-0184-3467
Lisa C RosenblattGlobal HEOR Oncology, Bristol Myers Squibb, Princeton, NJ, USA.
Xin YinGlobal HEOR Oncology, Bristol Myers Squibb, Princeton, NJ, USA.ORCID 0000-0002-4441-4585
Viviana Del TejoGlobal HEOR Oncology, Bristol Myers Squibb, Princeton, NJ, USA.
Sarah B GuttenplanGlobal HEOR Oncology, Bristol Myers Squibb, Princeton, NJ, USA.
Flavia EjzykowiczGlobal HEOR Oncology, Bristol Myers Squibb, Princeton, NJ, USA.
Kathleen BeusterienReal World Evidence, Oracle Life Sciences, Austin, TX, USA.
Oliver WillReal World Evidence, Oracle Life Sciences, Austin, TX, USA.ORCID 0000-0002-6514-8298
deMauri S MackieReal World Evidence, Oracle Life Sciences, Austin, TX, USA.
Grace SkilesReal World Evidence, Oracle Life Sciences, Austin, TX, USA.ORCID 0000-0003-0921-7356
Marc DeCongelioReal World Evidence, Oracle Life Sciences, Austin, TX, USA.ORCID 0009-0004-5486-5584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The treatment landscape for advanced/metastatic renal cell carcinoma (aRCC) has evolved quickly with the introduction of immunotherapies as a first-line treatment option. This study examined the preferences of patients with aRCC to better understand the characteristics of preferred treatments and the tradeoffs patients are willing to make when choosing treatment. Methods and Materials: An online, cross-sectional survey was conducted in the US from May to August 2022 with adult patients with aRCC. A discrete-choice experiment assessed treatment preferences for aRCC. Attributes were identified through literature review and qualitative interviews and included progression-free survival, survival time, objective response rate, duration of response, risk of serious side effects, quality of life (QoL), and treatment regimen. Results: Survey results from 299 patients with aRCC were analyzed. Patients had a mean age of 55.7 years, were primarily White (50.5%) and were evenly representative of males (49.8%) and females (48.8%). Improvements in all attributes influenced treatment choice. On average, increasing survival time from 10% to 55% was most important, followed by improvements in QoL (ie, from worsens a lot to improves) and improvements to treatment regimen convenience (ie, less frequent infusions). Risk of serious adverse events and increased progression-free time, objective response rate (ORR), and duration of response (DOR) were of lesser importance. Conclusion: In this study, patients highlighted that improving survival time was the most important and that QoL is also an important consideration. Discussions during treatment decision-making may benefit from broader conversations around treatment characteristics, including impacts on QoL and convenience of the regimen.

Indexed as

discrete choice experimentpatient preferencerenal cell carcinomatreatment preference

Identifiers

PMID39161803
PMCPMC11332422

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.