Evidence map›Paper›PMID 39161829›Full record

ArticleHeliyon2024

Synthesis and molecular structure exploration of novel piperidin-4-one imine derivatives combined with DFT and X-ray: A new class of antioxidant and anti-inflammatory agents.

Rubina Siddiqui, Sana Shamim, Shamim Akhter, Samia Kausar, Sammer Yousuf, Ataf Ali Altaf, Zafar Saeed Saify, Fuad Ameen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rubina SiddiquiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical, Sciences, University of Karachi, Karachi, 75270, Pakistan.
Sana ShamimDepartment of Pharmaceutical Chemistry, Dow College of Pharmacy, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan.
Shamim AkhterDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University Karachi, Pakistan.
Samia KausarDepartment of Chemistry, University of Gujrat, Gujrat, 50700, Pakistan.
Sammer YousufH. E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University, of Karachi, Karachi, 75270, Pakistan.
Ataf Ali AltafDepartment of Chemistry, University of Gujrat, Hafiz Hayat Campus, Gujrat, 50700, Pakistan.
Zafar Saeed SaifyDepartment of Chemistry, University of Gujrat, Hafiz Hayat Campus, Gujrat, 50700, Pakistan.
Fuad AmeenDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is one of the pertinent responses of the body, depending mainly on the process and factors involved in combating the oxidative species produced either by any infection or failure of the antioxidant pathways. In search of new compounds to exhibit antioxidant and anti-inflammatory activity here, we have successfully reported the synthesis of three novel compounds of Piperidin-4-one skeleton by adopting simple and convenient methods. Compound

Indexed as

ADMETAnti-inflammatoryAntioxidant activityDFT calculationImine derivativesPiperidin-4-oneSpectroscopyXRD

Identifiers

PMID39161829
PMCPMC11332821

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.