Evidence map›Paper›PMID 39162885›Full record

ReviewCell biology and toxicology2024

Metal ions overloading and cell death.

Yun Lai, Fen Fen Gao, Ruo Ting Ge, Rui Liu, Shumei Ma, Xiaodong Liu

Abstract readReview
In one paragraph

Review in Cell biology and toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Caffeic Acid Protects Keratinocytes from PMBiomolecules & therapeutics · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. The role of metal ions iron, copper, and zinc in the immune microenvironment of gastric cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  13. Article
  14. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  15. Review
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yun LaiSchool of Public Health, Wenzhou Medical University, Wenzhou, China.
Fen Fen GaoSchool of Public Health, Wenzhou Medical University, Wenzhou, China.
Ruo Ting GeSchool of Public Health, Wenzhou Medical University, Wenzhou, China.
Rui LiuSchool of Public Health, Wenzhou Medical University, Wenzhou, China.
Shumei MaSchool of Public Health, Wenzhou Medical University, Wenzhou, China. shmm2001@126.com.
Xiaodong LiuSchool of Public Health, Wenzhou Medical University, Wenzhou, China. liuxd2014@126.com.

Funding

Zhejiang Provincial University Student Sci&Tech Innovation Activity Plan and New Seedling Talent Plan NO.2023R413079
6 · The paper itself

Abstract

Cell death maintains cell morphology and homeostasis during development by removing damaged or obsolete cells. The concentration of metal ions whithin cells is regulated by various intracellular transporters and repositories to maintain dynamic balance. External or internal stimuli might increase the concentration of metal ions, which results in ions overloading. Abnormal accumulation of large amounts of metal ions can lead to disruption of various signaling in the cell, which in turn can produce toxic effects and lead to the occurrence of different types of cell deaths. In order to further study the occurrence and development of metal ions overloading induced cell death, this paper reviewed the regulation of Ca

Indexed as

Cell DeathMetalsReactive Oxygen SpeciesAnimalsApoptosisHomeostasisHumansIonsOxidative StressIonsMetalsReactive Oxygen SpeciesApoptosisAutophagyCuprotosisFerroptosisIons overloadingNecrosis

Identifiers

PMID39162885
PMCPMC11335907

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.