Evidence map›Paper›PMID 39164430›Full record

ArticleThe AAPS journal2024

A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions.

Tianshu Gu, Guiying Wang, Edwin J C van den Oord, Emanuel Goldman, Chengyuan Yang, Ning Xie, Lan Yao, Cong-Yi Wang, Monica Jablonski, Kunal Ray and 9 more

Abstract readLetter
PubMed Publisher
In one paragraph

Article in The AAPS journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tianshu GuDepartment of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, Tennesse, 38103, USA.
Guiying WangGeneral Surgery, The 2nd Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, Hebei, China.
Edwin J C van den OordCenter for Biomarker Research and Precision Medicine (BPM), Virginia Commonwealth University, VCU Health Sciences Research Building, Room 216A, P. O. Box 980533, Richmond, Virgina, 23298-0581, USA.
Emanuel GoldmanDepartment of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, 07103, USA.
Chengyuan YangDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA.
Ning XieCollege of Business, University of Louisville, Louisville, Kentucky, 40292, USA.
Lan YaoDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA.
Cong-Yi WangThe Centre for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Monica JablonskiDepartment of Ophthalmology, University of Tennessee Health Sciences Center, Memphis, Tennesse, USA.
Kunal RaySchool of Biological Science, Ramkrishna Mission Vivekananda Education & Research Institute, Narendrapur, 700103, West Bengal, India.
Fengxia LiuResearch Center, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050011, China.
Wensen PanRespiratory Medicine and Intensive Care, The 2, Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, Hebei, China.
Gonzalo FloresInstituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, San Manuel, 72570, Puebla, Mexico.
Lotfi AleyaChrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, 25030, Besançon Cedex, France.
Xia MengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, PR China.
Yan JiaoDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA.
Minghui LiDepartment of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, Tennesse, 38103, USA. mli54@uthsc.edu.
Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, PR China. Yongjunwang1962@gmail.com.
Weikuan GuDepartment of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, Tennesse, 38163, USA. wgu@uthsc.edu.ORCID 0000-0003-1112-8088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug labeling and instructions provide essential information for patients regarding the usage of drugs. Instructions for the dosage of drug usage are critical for the effectiveness of the drug and the safety of patients. The dosage of many drugs varies depending on the patient's age. However, as our understanding of human biology deepens, we believe that these instructions need to be modified to incorporate different life stages. This is because human biology and metabolism differ significantly among different life stages, and their responses to drugs also vary. Additionally, the same age of different persons may fall into different life stages. Therefore, our group from multiple institutes and countries proposes a reexamination of whether incorporating life stages in all or any drug instructions will greatly enhance drug efficiency and patients' health.

Indexed as

Drug LabelingAge FactorsHumansPharmaceutical PreparationsPharmaceutical PreparationsDiseaseDrug labelingLife stageMetabolismPuberty

Identifiers

PMID39164430

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.