Evidence map›Paper›PMID 39164640›Full record

Observational studyBMC ophthalmology2024

Multimodal imaging to distinguish microvascular and morphological changes in retinal vein occlusion after intravitreal ranibizumab with or without triamcinolone acetonide injection.

Nan Wang, Jingling Zou, Shengguo Li, Xianghui Deng, Jun Zeng, Chun Ding

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nan Wang *Department of Ophthalmology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China.
Jingling Zou *Department of Ophthalmology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
Shengguo LiChangsha Aier Eye Hospital, Changsha, Hunan Province, China.
Xianghui DengDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China.
Jun ZengDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China.
Chun DingDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China. chunding@csu.edu.cn.

Funding

Natural Science Foundation of Changsha No. kq2208494Natural Science Foundation of Hunan Province No.2023JJ30003Natural Science Foundation of Hunan Province No.2023JJ30748Science and Technology Program of Changsha No.kh2302036Scientific Research Project of Hunan Provincial Health Commission No.C202307027337Scientific Research Project of Hunan Provincial Health Commission No.D202307028349
6 · The paper itself

Abstract

backgroundThe study was designed to investigate microvascular and morphological changes in retinal vein occlusion (RVO) using multimodal imaging after intravitreal ranibizumab (IVR) with or without triamcinolone acetonide (IVTA) injections.

methodsThis was a retrospective and observational study. Fifty patients (52 eyes) diagnosed with RVO were enrolled. Best corrected visual acuity (BCVA), ophthalmoscopy, fundus fluorescein angiography (FFA), spectral domain optical coherence tomography (SDOCT), and optical coherence tomography angiography (OCTA) were employed sequentially both before treatment and at the last visit after treatment.

resultsThe mean logMAR VAs in BRVO eyes decreased significantly after treatment (P = 0.029). OCTA showed there was a significant difference in foveal avascular zone (FAZ) in BRVO eyes (P = 0.024), superificial foveal vessel density in both CRVO (P = 0.0004) and BRVO eyes (P = 0.02155). OCT showed the foveal thickness had significant differences after treatment in both CRVO (P < 0.0001) and BRVO eyes (P = 0.0001). BCVA was associated most commonly with ellipsoid zone integrity (P = 0.022). The BCVA in eyes treated with IVR and IVTA was significantly decreased compared with IVR only in BRVO group (P = 0.021). However, the combination of IVR + IVTA significantly improved intraocular pressure (IOP) compared with IVR only in BRVO group (P = 0.037).

conclusionBoth IVR and IVR + IVTA can significantly improve the central vision, macular structure, and functions in BRVO group. Simultaneous IVR with IVTA can significantly increase BCVA compared with IVR only in BRVO group.

Indexed as

Angiogenesis InhibitorsIntravitreal InjectionsMicrovesselsMultimodal ImagingRanibizumabRetinal Vein OcclusionTriamcinolone AcetonideAgedDrug Therapy, CombinationFemaleFluorescein AngiographyGlucocorticoidsHumansMaleMiddle AgedRetinal VesselsAngiogenesis InhibitorsGlucocorticoidsRanibizumabTriamcinolone AcetonideIntravitreal ranibizumab injectionIntravitreal triamcinolone acetonide injectionMicrovascular and morphological changesMultimodal imagingOptical coherence tomography angiographyRetinal vein occlusion

Identifiers

PMID39164640
PMCPMC11334535

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.