ArticleLipids in health and disease2024
Relationship of the trajectory of the triglyceride-glucose index with heart failure: the Kailuan study.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Triglyceride-glucose index and its derivatives, biventricular remodeling, and risk of incident heart failure: a large-scale prospective CMR study.Lipids in health and disease · 2026Article
- Association between triglyceride-glucose index and heart failure in patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Prognostic value of the triglyceride-glucose Index in elderly patients with acute decompensated heart failure: a one-year mortality analysis.Frontiers in cardiovascular medicine · 2026Article
- Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications.Frontiers in pharmacology · 2026Review
- Association between 10-year atherosclerotic cardiovascular disease risk score and incident cardiovascular events across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from the China health and retirement longitudinal study (CHARLS).BMC cardiovascular disorders · 2025Article
- The novel triglyceride‒glucose-weighted adjusted waist index as a supplementary diagnostic tool for heart failure: evidence of improved reclassification beyond traditional TyG-related indices from a cross-sectional study.Cardiovascular diabetology · 2025Article
- Insulin resistance markers HOMA-IR, TyG and TyG-BMI index in relation to heart failure risk: NHANES 2011-2016.PloS one · 2025Article
- Association between triglyceride-glucose index and 6-month readmission in patients with heart failure: a cohort study.Frontiers in cardiovascular medicine · 2025Article
- Association between triglyceride-glucose index and estimated 10-year risk of cardiovascular disease in Nigerian non-diabetic hypertensives: A cross-sectional study.PLOS global public health · 2025Article
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13 authors.
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Abstract
backgroundA high triglyceride-glucose index (TyG) is associated with a higher risk of incident heart failure. However, the effects of longitudinal patterns of TyG index on the risk of heart failure remain to be characterized. Therefore, in the present study, we aimed to characterize the relationship between the trajectory of TyG index and the risk of heart failure.
methodsWe performed a prospective study of 56,149 participants in the Kailuan study who attended three consecutive surveys in 2006-2007, 2008-2009, and 2010-2011 and had no history of heart failure or cancer before the third wave survey (2010-2011). The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2], and we used latent mixture modeling to characterize the trajectory of the TyG index over the period 2006-2010. Additionally, Cox proportional risk models were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for incident heart failure for the various TyG index trajectory groups.
resultsFrom 2006 to 2010, four different TyG trajectories were identified: low-stable (n = 13,554; range, 7.98-8.07), moderate low-stable (n = 29,435; range, 8.60-8.65), moderate high-stable (n = 11,262; range, 9.31-9.30), and elevated-stable (n = 1,898; range, 10.04-10.25). A total of 1,312 new heart failure events occurred during a median follow-up period of 10.04 years. After adjustment for potential confounders, the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident heart failure for the elevated-stable, moderate high-stable, and moderate low-stable groups were 1.55 (1.15, 2.08), 1.32 (1.08, 1.60), and 1.17 (0.99, 1.37), respectively, compared to the low-stable group.
conclusionsHigher TyG index trajectories were associated with a higher risk of heart failure. This suggests that monitoring TyG index trajectory may help identify individuals at high risk for heart failure and highlights the importance of early control of blood glucose and lipids for the prevention of heart failure.
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