Evidence map›Paper›PMID 39164726›Full record

ArticleBMC oral health2024

Possible Association between Behçet's Disease and Periodontal diseases.

Fikriye Orduyilmaz, Nurdan Ozmeric, Serenay Elgun, Sühan Gürbüz, Hamit Kucuk, Berivan Bitik, Abdurrahman Tufan, Berna Göker

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fikriye OrduyilmazTopraklik Oral and Dental Health Center, Ankara, Turkey.
Nurdan OzmericFaculty of Dentistry, Department of Periodontology, Gazi University, Ankara, Turkey. nurdan@gazi.edu.tr.
Serenay ElgunFaculty of Medicine, Department of Medical Biochemistry, Ankara University, Ankara, Turkey.
Sühan GürbüzFaculty of Dentistry, Department of Periodontology, Gazi University, Ankara, Turkey.
Hamit KucukFaculty of Medicine, Department of Rheumatology, Gazi University, Ankara, Turkey.
Berivan BitikFaculty of Medicine, Department of Rheumatology, Baskent University, Ankara, Turkey.
Abdurrahman TufanFaculty of Medicine, Department of Rheumatology, Gazi University, Ankara, Turkey.
Berna GökerFaculty of Medicine, Department of Rheumatology, Gazi University, Ankara, Turkey.

Funding

Gazi Üniversitesi 03/2016-01
6 · The paper itself

Abstract

aimThis study explores the connection between Behçet's disease (BD), characterized by persistent oral and genital ulcers alongside iritis, and periodontal disease. It examines the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nitric oxide (NO) in gingival crevicular fluid (GCF) and saliva.

methodsForty Behçet's patients with gingivitis or periodontitis and 47 patients with either gingivitis or periodontitis but without BD were studied. Periodontal status was recorded with standard clinical indexes. GCF and saliva samples were obtained. NO, IL-1β and TNF-α levels were analysed. Current Behçet's symptoms and medications usage were recorded.

resultsMean salivary IL-1β was elevated (p = .045), and mean NO level was decreased in BD patients with gingivitis compared to patients without BD (p = .000). In contrast, mean NO level in crevicular fluid was higher in Behçet's patients with periodontitis than in patients without BD (p = .009). Furthermore, among Behçet's patients, those with vascular involvement had lower salivary NO level compared to patients without vascular involvement (p = .000).

conclusionsBased on our findings, the elevated levels of IL-1β in the saliva of Behçet's patients with gingivitis, along with the decreased NO level, indicate an altered inflammatory response in the oral cavity.

Indexed as

Behcet SyndromeGingival Crevicular FluidGingivitisInterleukin-1betaNitric OxideSalivaTumor Necrosis Factor-alphaAdultFemaleHumansMaleMiddle AgedPeriodontal Attachment LossPeriodontal IndexPeriodontal PocketPeriodontitisInterleukin-1betaNitric OxideTumor Necrosis Factor-alphaBehçet’s diseaseGingivitisIL-1βNitric oxidePeriodontitisTNF-α

Identifiers

PMID39164726
PMCPMC11334455

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.