Evidence mapPaperPMID 39166702Full record

ArticleACS chemical neuroscience2024

Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates.

Marcin Jakubiec, Michał Abram, Mirosław Zagaja, Katarzyna Socała, Vanja Panic, Gniewomir Latacz, Szczepan Mogilski, Małgorzata Szafarz, Joanna Szala-Rycaj, Jerry Saunders and 12 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Marcin JakubiecDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
Michał AbramDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.ORCID 0000-0001-9738-3359
Mirosław ZagajaDepartment of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland.
Katarzyna SocałaDepartment of Animal Physiology and Pharmacology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, Lublin 20-033, Poland.ORCID 0000-0001-7706-2080
Vanja PanicDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.
Gniewomir LataczDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
Szczepan MogilskiDepartment Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
Małgorzata SzafarzDepartment of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
Joanna Szala-RycajDepartment of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland.
Jerry SaundersDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.
Peter J WestDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.
Dorota NieoczymDepartment of Animal Physiology and Pharmacology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, Lublin 20-033, Poland.
Katarzyna Przejczowska-PomiernyDepartment of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
Bartłomiej SzulczykChair and Department of Pharmacotherapy and Pharmaceutical Care, Centre for Preclinical Research and Technology, Medical University of Warsaw, Banacha 1B, Warsaw 02-097, Poland.
Anna KrupaDepartment of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
Elżbieta WyskaDepartment of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.ORCID 0000-0002-4798-0574
Piotr WlaźDepartment of Animal Physiology and Pharmacology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, Lublin 20-033, Poland.ORCID 0000-0002-5389-0241
Cameron S MetcalfDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.
Karen WilcoxDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0002-1510-0405
Marta Andres-MachDepartment of Experimental Pharmacology, Institute of Rural Health, Jaczewskiego 2, Lublin 20-950, Poland.
Rafał M KamińskiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
Krzysztof KamińskiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.ORCID 0000-0003-2103-371X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across

Indexed as

AnalgesicsAnticonvulsantsSeizuresAnimalsBrain-Derived Neurotrophic FactorDisease Models, AnimalDrug DiscoveryElectroshockGlycineHippocampusHumansKindling, NeurologicMaleMicePainPentylenetetrazoleAnalgesicsAnticonvulsantsBrain-Derived Neurotrophic FactorGlycinePentylenetetrazoleantinociceptive activityantiseizure activityhybrid moleculesin vitro ADME-Tox studiesin vitro functional studiesmultimechanistic compounds

Identifiers

PMID39166702
PMCPMC11378297

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.