ArticleInflammopharmacology2024
Neutrophil-lymphocyte ratio and systemic immune-inflammation index as predictors of cardiovascular risk and mortality in prediabetes and diabetes: a population-based study.
Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Article
- Complete Blood Count-Derived Inflammatory Indices in Prediabetes: A Head-to-Head Comparison.Journal of clinical medicine · 2026Article
- Risk correlation analysis of serum adiponectin (APN), D-dimer (DD) and the neutrophil - lymphocyte ratio (NLR) with the prognosis of diabetic foot ulcer infection.Journal of medical biochemistry · 2026Article
- Association Between Neutrophil-to-Lymphocyte Ratio and Mortality Risk Among Patients With Hyperlipidemia Across Different Glycemic Status: A Longitudinal Cohort Study From NHANES 1999-2018.Reviews in cardiovascular medicine · 2026Article
- Blood glucose mediation of the association between SIRI and mortality in T2DM complicated with ischemic stroke.Scientific reports · 2026Article
- Association of nine composite inflammatory indices with cardiovascular diseases in US adults: national health and nutrition examination survey (NHANES, 2005-2018).Journal of health, population, and nutrition · 2026Article
- Cross-sectional associations and incremental discrimination of inflammatory and lipid-derived indices for prevalent coronary heart disease in type 2 diabetes.Frontiers in endocrinology · 2026Article
- Association between novel inflammatory indices and osteoporosis among older adults: evidence from a large multicenter study in China.Frontiers in medicine · 2026Article
- Comparative associations of immune-inflammatory, immune-lipid, and metabolic composite indices with hyperuricemia among Chinese adults with glycemic abnormalities: a health examination-based cross-sectional study.Frontiers in endocrinology · 2026Observational
- Comparative screening performance and multicenter validation of novel inflammatory biomarkers (NLR, SII, and CAR) for risk stratification of diabetic foot ulcer in patients with type 2 diabetes mellitus.Frontiers in medicine · 2026Article
- Atrial fibrillation identification in patients with non-alcoholic fatty liver disease: a machine learning model based on immune-inflammatory markers.Diabetology & metabolic syndrome · 2025Article
- Systemic inflammatory indexes as predictors of 18-month mortality among cirrhotic patients receiving transjugular intrahepatic portosystemic shunt.Annals of medicine · 2025Article
- Therapeutic Modulation Of Peripheral Blood Cells And Inflammatory Indices During 52 Weeks Of Risankizumab In Responder Patients With Moderate-to-Severe Psoriasis: Results From A Multicenter Prospective Study.Dermatology practical & conceptual · 2025Article
- Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999-2018 cohort.Scientific reports · 2025Article
- Association between estimated glucose disposal rate and cardiovascular disease prevalence and mortality outcomes in metabolic dysfunction-associated steatotic liver disease: a comparative analysis of insulin resistance markers.Journal of global health · 2025Article
- Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients.Scientific reports · 2025Article
- Prognostic implications of systemic immune-inflammation index and systemic inflammation response index in hemodialysis patients.BMC nephrology · 2025Article
- Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker for Long-Term Survival in Older Adults at a Mental Health Care Center: A Historical Cohort Analysis.Journal of clinical medicine · 2025Article
- Neutrophil-lymphocyte ratio is a predictor for all-cause and cardiovascular mortality in individuals with prediabetes in a National study.Endocrine · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundThe neutrophil-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) are emerging inflammatory markers related to cardiovascular outcomes. This study investigated their relationships with cardiovascular disease (CVD) and mortality among individuals with prediabetes or diabetes and assessed their predictive roles.
methodsA cohort of 6871 individuals with diabetes or prediabetes from the NHANES (2001-2018) was included. Weighted multivariate logistic regression models assessed NLR and SII associations with CVD risk, while survey-weighted Cox proportional hazards models evaluated their links to mortality. The predictive accuracy of the biomarkers for mortality was quantified by receiver-operating characteristic (ROC) curve analysis.
resultsIndividuals in the higher NLR and SII groups exhibited a high incidence of CVD. A total of 1146 deaths occurred throughout an average follow-up duration of 191 months, of which 382 were caused by CVD. Participants with higher NLR markedly increased the risk of all-cause (HR = 1.82) and cardiovascular mortality (HR = 2.07). A similar result was observed in the higher SII group. RCS analysis identified a linear correlation between NLR and CVD risk and mortality (p > 0.05), while SII showed a nonlinear correlation (p < 0.05). ROC results demonstrated that NLR exhibited a higher predictive ability in mortality than SII.
conclusionsElevated levels of NLR and SII correlated with an increased risk of CVD and both all-cause and cardiovascular mortality in individuals with diabetes or prediabetes. The NLR appears to be particularly valuable for assessing risk and predicting outcomes in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.