Evidence map›Paper›PMID 39167321›Full record

ArticleInflammation2025

atRA Attenuates High Salt-Driven EAE Mainly Through Suppressing Th17-Like Regulatory T Cell Response Mediated by the Inhibition of IL-23R Signaling Pathway.

Jiale Tian, Yating Li, Shuo Gao, Yong Wang, Haolin Li, Xiaofeng Wei, Jun Yang, Youquan Gu, Haidong Wang, Yang Luo

Abstract read
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In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiale Tian *The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, China.
Yating Li *The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, China.
Shuo Gao *The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, China.
Yong Wang *The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, China.
Haolin LiRheumatic Bone Disease Center, Gansu Hospital of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China.
Xiaofeng WeiKey Laboratory of Biotherapy and Regenerative Medicine, Lanzhou, 730000, Gansu, China.
Jun YangThe First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, China.
Youquan GuDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China.
Haidong WangRheumatic Bone Disease Center, Gansu Hospital of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China.
Yang LuoThe First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, China. ldyy_yluo@lzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High salt diet (HSD) is implicated in numerous disorders, which boosts Th17 cell development and weakens immunosuppressive function of regulatory T cells (Treg cells) Treg cells, leading to the exacerbation of EAE. However, little is known regarding the harness of excessive proinflammatory responses evoked by HSD. Here we show that atRA, a key vitamin A metabolite with multifaceted immunoregulatory properties has the potential in inhibiting the proinflammatory reaction of high salt. Treatment with atRA in vivo elicited the Treg generation in cervical and axillary lymph nodes (CALs), and in CNS of experimental autoimmune encephalomyelitis (EAE). Meanwhile, the proportion of Th17-like Treg cells (RORγt-positive or GM-CSF-positive Treg cells) decreased in CALs. atRA also inhibited IL-17A expression in CD4

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalReceptors, InterleukinSodium Chloride, DietaryTh17 CellsT-Lymphocytes, RegulatoryTretinoinAnimalsFemaleMiceMice, Inbred C57BLSignal Transductioninterleukin-23 receptor, mouseReceptors, InterleukinSodium Chloride, DietaryTretinoinAll-trans retinoid acid (atRA)Dendritic cellsExperimental autoimmune encephalomyelitis (EAE)Interleukin-23 receptor (IL-23R)Regulatory T cells (Treg cells)Serum- and glucocorticoid-regulated kinase 1-dependent (SGK1)Th17 cells

Identifiers

PMID39167321

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.