Evidence map›Paper›PMID 39167377›Full record

ArticleTranslational vision science & technology2024

Potential Diagnostic Biomarkers of tRNA-Derived Small RNAs in PBMCs for Nonproliferative Diabetic Retinopathy in Patients With Type 2 Diabetes Mellitus.

Chun Ding, Nan Wang, Aohua Peng, Zicong Wang, Bingyan Li, Xian Zhang, Jun Zeng, Yedi Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Transfer RNA Fragments in Diseases of Sensory Organs.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chun DingDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Nan WangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Aohua PengDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zicong WangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Bingyan LiDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xian ZhangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jun ZengDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yedi ZhouDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to reveal the altered expressions of transfer RNA (tRNA)-derived small RNAs (tsRNAs) in peripheral blood mononuclear cells and identify potential diagnostic biomarkers for nonproliferative diabetic retinopathy (NPDR) from patients with type 2 diabetes mellitus. Methods: Fifty-three patients diagnosed with type 2 diabetes mellitus were enrolled, including 25 patients with NPDR and 28 patients without diabetic retinopathy (DR) as the control group. A small RNA microarray was performed to screen the differentially expressed tsRNAs. Reverse transcriptase quantitative polymerase chain reaction was used to validate the significantly altered tsRNAs in a screening cohort and a verification cohort. The target genes, their enriched functions, and signaling pathways were predicted by bioinformatics analyses. Results: In total, 668 upregulated and 485 downregulated tsRNAs were found in the NPDR group by microarray. Eight tsRNAs were validated preliminarily to be altered significantly by reverse transcriptase quantitative polymerase chain reaction, and their target genes were enriched in cellular macromolecule metabolic process and ubiquitin-mediated proteolysis. The verification experiments confirmed the increased levels of 5'tiRNA-35-PheGAA-8, tRF3-28-PheGAA-1, and tRF3b-PheGAA-6, and the decreased levels of mt-tRF3-19-ArgTCG, mt-tRF3-20-ArgTCG, and mt-tRF3-21-ArgTCG in patients with NPDR, which may serve as potential biomarkers with clinical significance. Conclusions: The study recognized the tsRNA expression changes in peripheral blood mononuclear cells from patients with NPDR and discovered potential diagnostic biomarkers that hold clinical significance. Translational Relevance: The significantly altered tsRNAs identified in the study may serve as potential diagnostic biomarkers for patients with NPDR as well as possible molecular targets of the occurrence and development of DR.

Indexed as

BiomarkersDiabetes Mellitus, Type 2Diabetic RetinopathyLeukocytes, MononuclearRNA, TransferAgedFemaleGene Expression RegulationHumansMaleMiddle AgedReverse Transcriptase Polymerase Chain ReactionBiomarkersRNA, Transfer

Identifiers

PMID39167377
PMCPMC11343001

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.