Evidence map›Paper›PMID 39167553›Full record

ReviewAutoimmunity2024

HLA-transgenic mouse models to study autoimmune central nervous system diseases.

Kyle R Pressley, Lance Schwegman, Maria Montes De Oca Arena, Carol Chase Huizar, Scott S Zamvil, Thomas G Forsthuber

Abstract readReview
In one paragraph

Review in Autoimmunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kyle R PressleyDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
Lance SchwegmanDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
Maria Montes De Oca ArenaDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health at San Antonio, San Antonio, TX, USA.
Carol Chase HuizarDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
Scott S ZamvilDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Thomas G ForsthuberDepartment of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
The role of TNFR2 in ameliorating progressive encephalomyelitisR01NS117742 · NINDS · UNIVERSITY OF TEXAS SAN ANTONIO · PI FORSTHUBER, THOMAS G. · 2021 to 2025
$1.8M
UTSA ESTEEMED ProgramR25EB027605 · NIBIB · UNIVERSITY OF TEXAS SAN ANTONIO · PI ABU-LAIL, NEHAL IBRAHIM · 2019 to 2024
$1.6M
MARC at the University of Texas at San AntonioT34GM145507 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J, CASSILL, AARON · 2022 to 2024
$1.5M
NIBIB NIH HHS R25 EB027605NIGMS NIH HHS R25 GM060655NIGMS NIH HHS T34 GM145507NINDS NIH HHS R01 NS117742
6 · The paper itself

Abstract

It is known that certain human leukocyte antigen (HLA) genes are associated with autoimmune central nervous system (CNS) diseases, such as multiple sclerosis (MS), but their exact role in disease susceptibility and etiopathogenesis remains unclear. The best studied HLA-associated autoimmune CNS disease is MS, and thus will be the primary focus of this review. Other HLA-associated autoimmune CNS diseases, such as autoimmune encephalitis and neuromyelitis optica will be discussed. The lack of animal models to accurately capture the complex human autoimmune response remains a major challenge. HLA transgenic (

Indexed as

Disease Models, AnimalHLA AntigensMice, TransgenicAnimalsAutoimmune DiseasesCentral Nervous System DiseasesHumansMiceMultiple SclerosisNeuromyelitis OpticaHLA Antigensanimal modelHLAMultiple sclerosisneuroinflammationtransgenic

Identifiers

PMID39167553
PMCPMC11470778

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.