ArticleScience advances2024
A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors.
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In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- The ubiquitin-editing enzyme A20 (TNFAIP3): mechanisms of activation, biological function, diseases and therapeutic targets.Molecular biomedicine · 2026Review
- CCR7 orchestrates the malignant progression of memory B cells in MYC-overexpressing lymphoma.Cell death and differentiation · 2026Article
- Monogenic disorders of the TNF signalling pathway.Nature reviews. Rheumatology · 2026Review
- CAR T cell engineering impacts antigen-independent activation and co-inhibition.Molecular therapy. Methods & clinical development · 2025Article
- Update on new autoinflammatory disorders from the 2024 Pediatric Rheumatology European Society Congress.Pediatric rheumatology online journal · 2025Review
- Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting.Nature communications · 2025Article
- Clinical characteristics and treatment strategies for A20 haploinsufficiency in Japan: a national epidemiological survey.Frontiers in immunology · 2025Article
- Case Report: Exploring the spectrum of A20 haploinsufficiency in children.Frontiers in pediatrics · 2025Article
- AI in optimized cancer treatment: laying the groundwork for interdisciplinary progress.Oxford open immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Christoph SchultheißDivision of Medical Oncology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0001-9789-5776
Lisa PascholdInternal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0003-0020-1315
Alma Nazlie MohebianyInstitute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0001-9818-6867
Moritz EscherInternal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0009-0001-0059-481X
Yogita Mallu KattimaniInstitute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
Melanie MüllerInstitute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0009-0009-3082-256X
Paul Schmidt-BarboDivision of Medical Oncology, University Hospital Basel, Basel, Switzerland.
Anna Mensa-VilaróDepartment of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Juan Ignacio ArósteguiDepartment of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.ORCID 0000-0003-4757-504X
Guilaine BoursierDepartment of molecular and cytogenomics, Rare and Autoinflammatory Diseases Laboratory, CHU Montpellier, IRMB, University of Montpellier, INSERM, CEREMAIA, Montpellier, France.ORCID 0000-0002-2903-3135
Claire de MoreuilDepartment of Internal Medicine, CHU Brest, Université de Bretagne Occidentale, Brest, France.
Timo HautalaResearch Unit of Biomedicine, University of Oulu and Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.ORCID 0000-0001-7889-1614
Edith WillscherInternal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0002-8786-4578
Hanna JonasInternal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Namuun ChinchuluunInternal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Bianca GrosserInstitute for Pathology, University Medical Center Augsburg, Augsburg, Germany.
Bruno MärklInstitute for Pathology, University Medical Center Augsburg, Augsburg, Germany.ORCID 0000-0002-7704-850X
Wolfram KlapperInstitute of Pathology, Hematopathology Section, and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Prasad Thomas OommenDepartment of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0003-2893-7252
Katharina GösslingDepartment of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Katrin HoffmannInstitute for Human Genetics and Molecular Biology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Gisa TiegsInstitute for Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Felix CzernilofskyDepartment of Medicine V, Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0001-5868-2890
Sascha DietrichDepartment of Medicine V, Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Alexandra FreemanLaboratory of Clinical Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.ORCID 0000-0001-7005-8345
Daniella M SchwartzDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1660-8438
Ari WaismanInstitute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0003-4304-8234
Ivona AksentijevichInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6564-7214
Mascha BinderDivision of Medical Oncology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0003-0663-3004
Funding
Genetics, Pathophysiology, and Treatment of Dominant Autoinflammatory DiseasesZIAHG200373 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2024
$21.0MAbstract
Genetic
Indexed as
HaploinsufficiencyHomeostasisNF-kappa BTumor Necrosis Factor alpha-Induced Protein 3AdultAnimalsB-LymphocytesFemaleHumansLymphocytesLymphomaMaleMiceMice, KnockoutMiddle AgedSignal TransductionNF-kappa BTNFAIP3 protein, humanTnfaip3 protein, mouseTumor Necrosis Factor-alphaTumor Necrosis Factor alpha-Induced Protein 3
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.